Accelerating and improving the healing quality of wounded injuries required the development of new strategies for fully functional regeneration of skin tissues. In this work, electrospun nanofibrous scaffolds based on cellulose acetate (CA) encapsulated with modified hydroxyapatite (HAP) with different contents of Cu ions. It was shown from morphological features that prepared webs were formed in a non-oriented network with diameters around 1.4–6.9, 1.3–6.3, 0.6–3.1, 0.79–3.7, and 0.8–3.9 μm for 0.0Cu-HAP@CA, 0.2Cu-HAP@CA, 0.4Cu-HAP@CA, 0.6Cu-HAP@CA, and 0.8Cu-HAP@CA, respectively. The maximum roughness valley depth (R_v) was varied from 113.6 nm to 183.9 nm for the lowest and the highest Cu contributions. The mechanical properties were also investigated and showed that toughness was enhanced slightly from 3.2 ± 0.3 to 3.3 ± 0.4 MJ/m³ for 0.0Cu-HAP@CA and 0.6Cu-HAP@CA, respectively. Furthermore, the antibacterial behavior against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were tested, whereas the highest inhibition zones reached 6.3 ± 1.5 and 6.5 ± 1.1 mm for the highest addition Cu. Finally, human fibroblasts cell lines were cultivated in-vitro through the nanofibrous scaffold, and cells showed a high degree of response with proliferation and growing behaviors upon the compositional modification. Hence, tailoring of good dressings might be developed via nanofibrous scaffolds containing modified ceramics.

加速和改善伤口受伤的愈合质量需要开发新的策略来使皮肤组织完全恢复功能。在这项工作中，基于醋酸纤维素（CA）的静电纺丝纳米纤维支架被改性的羟基磷灰石（HAP）封装，具有不同的Cu离子含量。从形态学特征可以看出，对于0.0Cu-HAP@CA为0.2，制备的纤维网是在直径约1.4-6.9、1.3-6.3、0.6-3.1、0.79-3.7和0.8-3.9μm的无取向网络中形成的。 Cu-HAP @ CA，0.4Cu-HAP @ CA，0.6Cu-HAP @ CA和0.8Cu-HAP@CA。最大粗糙度谷深（R _v铜的最低和最高贡献值从113.6 nm变化到183.9 nm。还研究了机械性能，结果表明，对于0.0Cu-HAP@CA和0.6Cu-HAP@CA，韧性分别从3.2±0.3略微提高到3.3±0.4 MJ / m ³。此外，对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）的抗菌作用进行了测试，而最高添加铜的最高抑制区达到了6.3±1.5和6.5±1.1 mm。最后，通过纳米纤维支架体外培养人成纤维细胞细胞系，并且当组成改变时，细胞表现出高度的反应性，具有增殖和生长行为。因此，可以通过包含改性陶瓷的纳米纤维支架来开发良好的敷料。