With a rise in the incidence of autoimmune diseases (AiD), health care providers continue to seek out more efficacious treatment approaches for the AiD patient population. Classic serotonergic psychedelics have recently been gaining public and professional interest as novel interventions to a number of mental health afflictions. Psychedelics have also been shown to be able to modulate immune functions, however, while there has been great interest to researching into their psychotherapeutic applications, there has so far been very little exploration into the potential to treat inflammatory and immune-related diseases with these compounds. A handful of studies from a variety of fields suggest that psychedelics do indeed have effects in the body that may attenuate the outcome of AiD. This literature review explores existing evidence that psychedelic compounds may offer a potential novel application in the treatment of pathologies related to autoimmunity. We propose that psychedelics hold the potential to attenuate or even resolve autoimmunity by targeting psychosomatic origins, maladaptive chronic stress responses, inflammatory pathways, immune modulation and enteric microbiome populations.

随着自身免疫性疾病 (AiD) 发病率的上升，医疗保健提供者继续为 AiD 患者群体寻找更有效的治疗方法。经典的血清素能迷幻药最近作为对许多心理健康问题的新型干预措施引起了公众和专业人士的兴趣。迷幻药也被证明能够调节免疫功能，然而，虽然人们对研究它们的心理治疗应用很感兴趣，但迄今为止，对用这些化合物治疗炎症和免疫相关疾病的潜力的探索很少. 来自各个领域的少数研究表明，迷幻药确实对身体有影响，可能会减弱 AiD 的结果。这篇文献综述探讨了现有证据，即迷幻化合物可能在治疗与自身免疫相关的病理方面提供潜在的新应用。我们提出，迷幻药有可能通过靶向心身起源、适应不良的慢性应激反应、炎症通路、免疫调节和肠道微生物群来减弱甚至解决自身免疫问题。