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Association of personal exposure to power-frequency magnetic fields with pregnancy outcomes among women seeking fertility treatment in a longitudinal cohort study
Fertility and Sterility ( IF 6.7 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.fertnstert.2020.05.044
Mary E Ingle 1 , Lidia Mínguez-Alarcón 2 , Ryan C Lewis 1 , Paige L Williams 3 , Jennifer B Ford 2 , Ramace Dadd 2 , Russ Hauser 4 , John D Meeker 1 ,
Affiliation  

OBJECTIVE To assess for the first time the potential relationships of personal exposure to magnetic fields (MF) with pregnancy outcomes among a cohort of women from a fertility clinic, addressing, through study design, some of the primary limitations of previous studies on this topic. DESIGN Longitudinal preconception prospective cohort. SETTING Fertility center. PATIENT(S) Our analysis included 119 women recruited from 2012 to 2018, who underwent in vitro fertilization (IVF) (n = 163 cycles) and/or intrauterine insemination (IUI) (n = 123 cycles). INTERVENTION(S) Women wore personal exposure monitors continuously for up to three consecutive 24-hour time periods separated by several weeks. MAIN OUTCOME MEASURE(S) Implantation, clinical pregnancy, live birth, and pregnancy loss. RESULT(S) The median and maximum of the overall daily mean (daily peak) MF exposure levels were 1.10 mG (2.14 mG) and 15.54 mG (58.73 mG), respectively. MF exposure metrics were highest among women who changed environments four or more times per day. Overall, no statistically significant associations between MF exposure metrics and fertility treatment or pregnancy outcomes were observed in crude or adjusted models. Effect estimates, both positive and negative, varied by outcome and the exposure metric, including the way in which exposure was modeled. CONCLUSION(S) Personal MF exposures were not associated with fertility treatment outcomes or pregnancy outcomes. Despite its limited size, strengths of the study include a longitudinal repeated-measures design, the collection of personal MF exposure data across multiple days, and carefully documented outcome and covariate information among a potentially susceptible study population.

中文翻译:

在一项纵向队列研究中寻求生育治疗的女性个人接触工频磁场与妊娠结局的关联

目的 首次评估来自生育诊所的一组女性中个人暴露于磁场 (MF) 与妊娠结局的潜在关系,通过研究设计解决先前关于该主题的研究的一些主要局限性。设计纵向先入为主的前瞻性队列。设置生育​​中心。患者 我们的分析包括 2012 年至 2018 年招募的 119 名女性,她们接受了体外受精 (IVF)(n = 163 个周期)和/或宫腔内人工授精 (IUI)(n = 123 个周期)。干预措施 妇女连续佩戴个人暴露监测器长达三个连续的 24 小时时间段,间隔数周。主要结果测量(S)植入、临床妊娠、活产和流产。结果(S) 每日平均(每日峰值)MF 暴露水平的中位数和最大值分别为 1.10 mG (2.14 mG) 和 15.54 mG (58.73 mG)。MF 暴露指标在每天改变环境四次或更多次的女性中最高。总体而言,在原始模型或调整后的模型中未观察到 MF 暴露指标与生育治疗或妊娠结局之间存在统计学上的显着关联。影响估计,无论是积极的还是消极的,都因结果和暴露指标而异,包括暴露的建模方式。结论 (S) 个人 MF 暴露与生育治疗结果或妊娠结果无关。尽管规模有限,但该研究的优势包括纵向重复测量设计、多天个人 MF 暴露数据的收集、
更新日期:2020-11-01
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