In this issue of Cell Host & Microbe, Nielsen and colleagues sequence antibody repertoires of patients with severe COVID-19 to reveal potentially convergent features on the background of a larger, polyclonal response. Their findings suggest that, as databases improve, it may be possible to monitor virus-specific B cells after infection or vaccination using antibody sequencing.

中文翻译：

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挖掘抗体库以解决 SARS-CoV-2

在本期《Cell Host & Microbe》中，Nielsen 及其同事对重症 COVID-19 患者的抗体库进行了测序，以揭示在更大的多克隆反应背景下潜在的趋同特征。他们的研究结果表明，随着数据库的完善，有可能在感染或接种疫苗后使用抗体测序来监测病毒特异性 B 细胞。