Our aims were to assess performance of duodenal intraepithelial lymphocyte counting for diagnosis of Helicobacter pylori (H. pylori) gastritis, and effects of eradication therapy on intraepithelial lymphocytosis. Paired duodenal and gastric biopsies from subjects with a pathologic diagnosis of H. pylori gastritis were reviewed. Higher duodenal intraepithelial lymphocyte counts were observed in 40 subjects with H. pylori gastritis (26 ± 5 per villus) than 52 subjects negative for H. pylori (12 ± 2 per villus). After successful eradication therapy, duodenal lymphocytes were indistinguishable from H. pylori–negative subjects, whereas they remained elevated after failed eradication therapy. This study confirms previous reports of increased duodenal intraepithelial lymphocytes in patients with concurrent Helicobacter pylori gastritis. Intraepithelial lymphocyte counts of > 15 per villus or > 10 per 100 enterocytes were predictive of infection. Duodenal lymphocytosis decreases significantly after successful eradication therapy but remains elevated when treatment fails.

我们的目标是，以评估诊断十二指肠上皮内淋巴细胞计数的性能幽门螺杆菌（^ h。幽门螺旋杆菌）胃炎，和上皮内淋巴细胞根除治疗的效果。配对的十二指肠和胃活检与H的病理诊断。回顾性幽门胃炎。在40例H病患者中观察到十二指肠上皮内淋巴细胞计数较高。幽门螺杆菌胃炎（每个绒毛26±5）比H阴性的52名受试者好。幽门螺杆菌（每个绒毛12±2）。在成功根除治疗后，十二指肠淋巴细胞与^ h。幽门螺杆菌阴性患者，而根除治疗失败后仍保持较高水平。这项研究证实了既往有幽门螺杆菌胃炎患者十二指肠上皮内淋巴细胞增多的报道。绒毛上皮内淋巴细胞计数每绒毛> 15或每100肠细胞> 10可预示感染。成功的根除治疗后，十二指肠淋巴细胞增多显着减少，但治疗失败后则保持升高。