Objectives

Meta-analysis was used to determine the association between rs3751143 polymorphism of P2RX7 gene and the risk of chronic lymphocytic leukemia (CLL).

Methods

Search for published articles about the association between the rs3751143 and CLL in PubMed, MEDINE, Web of Science, and Embase databases, with a calculated odds ratio of (OR) and 95% confidence interval (95%CI).

Results

A total of 1184 cases and 1725 controls in 8 studies were pooled together for evaluation of the overall association between rs3751143 and risk of CLL. Allele model (A vs C, p = 0.16, OR = 0.85, 95%CI = 0.71–1.17), homozygous model (AA vs CC, p = 0.07; OR = 0.78, 95%CI = 0.84–1.08), and heterozygous model (AC vs CC, p = 0.76; OR = 0.85; 95%CI = 0.68–0.79) did not show decreased risk of developing CLL. Similarly, dominant model (AA + AC vs. CC: p = 0.58; OR = 1.10, 95%CI = 0.69–1.75), and recessive model (AA vs AC + CC, p = 0.21, OR = 1.18, 95%CI = 0.70–1.99) failed to show decreased risk of developing CLL. However, in familial, heterozygous model (AC vs. CC: p = 0.0006, OR = 0.64, 95%CI = 0.67–1.50) and recessive model (AA vs. AC + CC: p = 0.0017; OR = 1.02, 95%CI = 0.73–2.35) indicated the association between the inheritance of rs3751143 and the risk of developing CLL. In the overall survival prognosis, no significant association between rs3751143 and CLL was detected with relatively high heterogeneity.

Conclusions

Our pooled data indicates that there is a correlation between the inheritance of rs3751143 and the risk of CLL in familial.

中文翻译：

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P2RX7基因rs3751143多态性与慢性淋巴细胞白血病相关性的荟萃分析

目标

采用Meta分析确定P2RX7基因rs3751143多态性与慢性淋巴细胞白血病（CLL）风险的相关性。

方法

在 PubMed、MEDINE、Web of Science 和 Embase 数据库中搜索关于 rs3751143 和 CLL 之间关联的已发表文章，计算优势比为 (OR) 和 95% 置信区间 (95%CI)。

结果

将 8 项研究中的 1184 名病例和 1725 名对照合并在一起，以评估 rs3751143 与 CLL 风险之间的整体关联。等位基因模型（A vs C，p  = 0.16，OR = 0.85，95%CI = 0.71–1.17）、纯合模型（AA vs CC，p  = 0.07；OR = 0.78，95%CI = 0.84–1.08）和杂合子模型（AC 与 CC，p  = 0.76；OR = 0.85；95%CI = 0.68–0.79）未显示发生 CLL 的风险降低。同样，显性模型（AA + AC vs. CC：p  = 0.58；OR = 1.10，95%CI = 0.69–1.75）和隐性模型（AA vs AC + CC，p  = 0.21，OR = 1.18，95 %CI = 0.70–1.99) 未能显示发生 CLL 的风险降低。然而，在家族性杂合模型中（AC vs. CC：p = 0.0006，OR = 0.64，95%CI = 0.67–1.50）和隐性模型（AA vs. AC + CC：p  = 0.0017；OR = 1.02, 95%CI = 0.73–2.35）表明 rs3751143 的遗传之间存在关联和发展 CLL 的风险。在总体生存预后中，未检测到 rs3751143 与 CLL 之间的显着关联，具有相对较高的异质性。

结论

我们的汇总数据表明，rs3751143 的遗传与家族性 CLL 风险之间存在相关性。