Development of science needs the cooperation of many creative brains. Sometimes, ideas on a specific area get suddenly exhausted and then it is the time for a privileged mind to think in a different way and reach the turning point to introduce a new paradigm. This happened to Geoffrey Burnstock, a heterodox thinker and nonconformist scientist that has been the paladin of purinergic signalling since 1972, opening neuroscience to the understanding of organs and tissues functioning and development of a new pharmacology. This review summarizes the contribution of our group to the understanding of the role of the diadenosine polyphosphates, Ap_nA, as signalling molecules, describing their tissue and organ distribution, their transport and storage in secretory vesicles and their release and interaction with purinergic receptors. We also have to acknowledge the friendly and kindly support of Professor Burnstock that showed a great interest in the field from our initial findings and actively stimulated our efforts to establish the extracellular roles and biological significance of these dinucleotides.

科学的发展需要许多富有创造力的大脑的合作。有时，特定领域的想法突然枯竭，然后是特权思想以不同方式思考并达到引入新范式的转折点的时候。这发生在杰弗里·伯恩斯托克 (Geoffrey Burnstock) 身上，他是一位异端思想家和不墨守成规的科学家，自 1972 年以来一直是嘌呤能信号的圣骑士，开启了神经科学对器官和组织功能的理解以及新药理学的发展。这篇综述总结了我们小组对理解多磷酸二腺苷的作用的贡献，Ap _nA，作为信号分子，描述它们的组织和器官分布，它们在分泌囊泡中的运输和储存以及它们的释放和与嘌呤能受体的相互作用。我们还必须感谢 Burnstock 教授的友好和善意支持，他从我们的初步发现中对该领域表现出极大的兴趣，并积极推动我们努力建立这些二核苷酸的细胞外作用和生物学意义。