The human microbiota typically contains symbionts and supports the host, although it can be commensal or reciprocal and pathogenic in its host function, immunity, and diet. Modern studies indicate that perturbations in the microbiome may be present in quite a few diseases, including inflammation and cancer. To be more specific, changes in the microbiomes of the gut and vagina may be related to various gynecologic cancers (cervical, uterine, and ovarian). Furthermore, the gastrointestinal microbiota can be altered by environmental factors and pre-existing morbidities and may cause nausea, vomiting, diarrhea, constipation, bloating, and abdominal pain. A healthy female gut microbiome is dominated by Bifidobacterium, Lactobacillus, Bacteroides, Clostridium, Escherichia, Streptococcus, and Ruminococcus; the vaginal microbiome includes Firmicutes, specifically Lactobacilli spp. However, the gram-variable coccobacillus Gardnerella vaginalis (previously known as Haemophilus vaginalis) dominates the microbiota of biological vaginosis (BV) and includes several anaerobic organisms. Vaginal microbiota perturbations can cause vaginal pain, sexual dysfunction, and urinary symptoms. In the current review paper, we explore recent research along with existing gaps in knowledge related to the association of changes in microbiota diversity and the pathogenesis of vaginal infection-associated cervical cancer.

中文翻译：

---

破解人类胃肠道菌群在阴道感染和宫颈癌发病机理中的作用

人类微生物群通常包含共生体并支持宿主，尽管它在宿主功能，免疫力和饮食方面可能是共生的或互惠的，并具有致病性。现代研究表明，微生物组中的干扰可能存在于许多疾病中，包括炎症和癌症。更具体地说，肠道和阴道微生物群的变化可能与各种妇科癌症（宫颈癌，子宫癌和卵巢癌）有关。此外，胃肠道微生物群可能会因环境因素和既往发病而改变，并可能引起恶心，呕吐，腹泻，便秘，腹胀和腹痛。健康的女性肠道微生物组主要由双歧杆菌，乳杆菌，拟杆菌，梭菌，大肠埃希氏菌，链球菌和球菌; 阴道微生物组包括Firmicutes，特别是乳酸杆菌属。然而，革兰氏可变球菌加德纳氏杆菌（以前称为阴道嗜血杆菌）在生物性阴道病（BV）的微生物群中占主导地位，并且包括几种厌氧性生物。阴道微生物群摄动会引起阴道疼痛，性功能障碍和泌尿系统症状。在当前的综述文件中，我们探索了最近的研究以及与微生物群多样性变化和阴道感染相关子宫颈癌发病机制相关的知识的空白。