The surface modification of polyvinylidene difluoride (PVDF) for various biomedical uses is notoriously hampered by the chemical inertness of the polymer. A wet chemical approach aiming at covalently grafting biomolecules was demonstrated by means of an elimination reaction of fluorine from the polymer backbone followed by subsequent modification steps. Exemplified as a possible biological application, the coupling of the peptide REDV rendered the material adhesive for endothelial cells while adhesion of thrombocytes was dramatically reduced.

中文翻译：

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使用湿化学对表面改性聚偏二氟乙烯的细胞行为进行调控

众所周知，用于各种生物医学用途的聚偏二氟乙烯 (PVDF) 的表面改性受到聚合物化学惰性的阻碍。一种旨在共价接枝生物分子的湿化学方法通过氟从聚合物主链中的消除反应以及随后的改性步骤来证明。作为可能的生物学应用，肽REDV的偶联使材料对内皮细胞具有粘附性，而血小板的粘附性显着降低。