The integration of electrochemical sensors in wearable consumer electronics enables monitoring the health status of individuals at molecular levels across the general population, and thus can play a critical role in transforming personalized and precision medicine. Previously, we devised a seamless integration strategy to interface disposable mediator-free enzymatic sensors—constructed on anisotropic conductive films (ACFs)—with consumer electronics. To illustrate the generalizability of our approach, here, we leverage ACF electrodes as a foundation to develop widely used mediator-based enzymatic sensors, which possess different underlying reaction mechanisms. Accordingly, we demonstrated the ACF-based sensor’s anti-corrosive performance and its compatibility for integration with contact pads on both flexible and rigid substrates. To position this mediator-based sensor for untreated biofluid analysis, we adopted a post-calibration methodology to facilitate sensor surface conditioning. To demonstrate the clinical utility of our approach, a representative mediator-based enzymatic glucose sensor was developed and coupled with contact pads on a circuit board to analyze the changes in sweat glucose levels with respect to meal intake (n = 26). The generalizability of the ACF-based sensor development and integration strategy allows for its adoption to target a wide panel of biomarkers and to transform the wearable consumer electronics into biosmart platforms. [2020-0193]

中文翻译：

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JMEMS 推出用于 Biosmart 可穿戴消费电子产品的粘性和耐腐蚀生物标志物传感膜

电化学传感器在可穿戴消费电子产品中的集成能够在分子水平上监测整个人群的健康状况，因此可以在转变个性化和精准医疗方面发挥关键作用。以前，我们设计了一种无缝集成策略，将一次性无介体酶传感器（构建在各向异性导电薄膜 (ACF) 上）与消费电子产品连接起来。为了说明我们方法的普遍性，在这里，我们利用 ACF 电极作为开发广泛使用的基于介体的酶传感器的基础，这些传感器具有不同的潜在反应机制。因此，我们展示了基于 ACF 的传感器的防腐性能及其与柔性和刚性基板上的接触垫集成的兼容性。为了将这种基于介质的传感器定位在未经处理的生物流体分析中，我们采用了后校准方法来促进传感器表面调节。为了证明我们的方法的临床效用，开发了一种代表性的基于介质的酶促葡萄糖传感器，并与电路板上的接触垫相结合，以分析汗液葡萄糖水平相对于膳食摄入量的变化（n = 26）。基于 ACF 的传感器开发和集成策略的通用性使其能够用于针对广泛的生物标志物，并将可穿戴消费电子产品转变为生物智能平台。[2020-0193] 开发了一种代表性的基于介质的酶葡萄糖传感器，并与电路板上的接触垫相结合，以分析汗液葡萄糖水平相对于膳食摄入量的变化（n = 26）。基于 ACF 的传感器开发和集成策略的通用性使其能够用于针对广泛的生物标志物，并将可穿戴消费电子产品转变为生物智能平台。[2020-0193] 开发了一种代表性的基于介质的酶葡萄糖传感器，并与电路板上的接触垫相结合，以分析汗液葡萄糖水平相对于膳食摄入量的变化（n = 26）。基于 ACF 的传感器开发和集成策略的通用性使其能够用于针对广泛的生物标志物，并将可穿戴消费电子产品转变为生物智能平台。[2020-0193]