To explore the value of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of molecular subtypes of breast cancer. Sixty-two cases of breast cancer were divided into luminal epithelium A or B subtype (luminal A/B), Her-2 over-expression subtype and triple negative subtype (TN). CEUS and routine ultrasonography were performed for all patients before surgery. (1) The luminal epithelium subtype contrast enhancement pattern was more likely to present with radial edge (76.92%, p < 0.05) and low perfusion (69.23%, p < 0.05). The maximum intensity (IMAX) was lower in the luminal epithelium subtype (p < 0.05). (2) The Her-2 over-expression subtype contrast enhancement pattern was more likely to present with centripetal enhancement (93.75%, p < 0.05) and perfusion defect (75.0%, p < 0.05), and the time to peak (TTP) was shorter (80.0%, p < 0.05). (3) The contrast enhancement pattern of the triple negative subtype was shown to have a clear boundary. Compared to the other two subtypes, the triple negative subtype did not have significantly different perfusion parameters (p > 0.05). (4) Our study showed that the areas under the ROC curve for radial edge, low perfusion and IMAX for the luminal epithelium subtype breast lesions were 76.5%, 75.6%, and 82.1%, respectively. Additionally, the areas under the ROC curve for centripetal enhancement, perfusion defect and TTP for the Her-2 over-expression subtype breast lesions were 68.6%, 92.4%, and 97.8%, respectively. The sensitivity, specificity, and diagnostic accuracy of clear boundaries in detecting triple negative subtype breast lesions were 90.5%, 80.0%, and 91.9%, respectively.

中文翻译：

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超声造影在不同分子亚型乳腺癌鉴别诊断中的应用

探讨对比增强超声（CEUS）在乳腺癌分子亚型鉴别诊断中的价值。62例乳腺癌分为管腔上皮A或B亚型(luminal A/B)、Her-2过表达亚型和三阴性亚型(TN)。所有患者术前均行 CEUS 和常规超声检查。(1)管腔上皮亚型对比度增强模式更可能呈现径向边缘（76.92%，p < 0.05）和低灌注（69.23%，p < 0.05）。管腔上皮亚型的最大强度 (IMAX) 较低 (p < 0.05)。(2) Her-2过表达亚型对比增强模式更可能出现向心增强(93.75%, p < 0.05)和灌注缺损(75.0%, p < 0.05)，达到峰值的时间 (TTP) 更短 (80.0%, p < 0.05)。(3)三阴性亚型的对比度增强模式具有清晰的边界。与其他两种亚型相比，三阴性亚型的灌注参数没有显着差异（p > 0.05）。(4)我们的研究表明，管腔上皮亚型乳腺病变径向边缘、低灌注和IMAX的ROC曲线下面积分别为76.5%、75.6%和82.1%。此外，Her-2 过度表达亚型乳腺病变的向心增强、灌注缺损和 TTP 的 ROC 曲线下面积分别为 68.6%、92.4% 和 97.8%。明确边界检测三阴性亚型乳腺病变的敏感性、特异性和诊断准确性分别为 90.5%、80.0% 和 91.9%。