Endometriosis, a chronic inflammatory disease, is identified by the presence of endometrial tissue outside the uterus. The prevalence of this disease among reproductive-age women is almost 10–15%. High levels of IL-6 and IL-8 have been found in the peritoneal fluid (PF) of women with endometriosis and are involved in its pathogenesis. Isolated stromal cells from 12 ectopic and eutopic endometrial biopsies of women with ovarian endometrioma and also 12 endometrial biopsies of nonendometriotic controls were treated with 1.1 µM pyrvinium pamoate, a Wnt/β-catenin signaling pathway inhibitor, for 72 hrs. Before treatment, mRNA gene expression and secretion of IL-6 and IL-8 were significantly higher in ectopic (EESCs) than eutopic (EuESCs) and control (CESCs) endometrial stromal cells. After treatment, mRNA gene expression and also secretion of IL-6 and IL-8 were significantly reduced. Our Findings showed that pyrvinium pamoate suppresses the mRNA gene expression and secretion of IL-6 and IL-8 in human endometriotic stromal cells. Additional investigations on this compound are required before clinical application.

子宫内膜异位症是一种慢性炎症性疾病，通过子宫外子宫内膜组织的存在来确定。这种疾病在育龄妇女中的患病率几乎为 10-15%。在子宫内膜异位症女性的腹腔液 (PF) 中发现了高水平的 IL-6 和 IL-8，并参与了其发病机制。从患有卵巢子宫内膜异位症的女性的 12 个异位和在位子宫内膜活检以及 12 个非子宫内膜异位症对照的子宫内膜活检中分离出的基质细胞，用 1.1 µM pyrvinium pamoate（一种 Wnt/β-catenin 信号通路抑制剂）处理 72 小时。治疗前，异位（EESCs）的mRNA基因表达和IL-6和IL-8的分泌显着高于在位（EuESCs）和对照（CESCs）子宫内膜基质细胞。治疗后，mRNA基因表达以及IL-6和IL-8的分泌显着降低。我们的研究结果表明，pyrvinium pamoate 抑制人子宫内膜异位基质细胞中 IL-6 和 IL-8 的 mRNA 基因表达和分泌。在临床应用之前需要对该化合物进行额外的研究。