Background: Infection is the most frequent complication after severe burns and has a propensity to progress into sepsis then septic shock and multiple organ dysfunction syndrome (MODS). Improving outcomes in acute burn care depends on early detection of infection to allow prompt interventions. Diagnosis of sepsis in severe burns is uniquely challenging because otherwise-typical clinical signs are masked by the hypermetabolic state and systemic inflammation induced by the burn itself. For this reason, burns have historically been excluded from high-impact studies on the diagnosis and treatment of sepsis.

中文翻译：

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烧伤感染和败血症的检测

背景：感染是严重烧伤后最常见的并发症，并且有发展成败血症的倾向，然后是败血性休克和多器官功能障碍综合征 (MODS)。改善急性烧伤护理的结果取决于感染的早期检测以允许及时干预。严重烧伤中败血症的诊断具有独特的挑战性，因为其他典型的临床症状被烧伤本身引起的高代谢状态和全身炎症所掩盖。出于这个原因，烧伤历来被排除在脓毒症诊断和治疗的高影响研究之外。