Background The Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog) and the Severe Impairment Battery (SIB) are widely used rating scales to assess cognition in Alzheimer’s disease. Objective To understand the correspondence between these rating scales, we aimed to examine the linkage of MMSE with the ADAS-Cog and SIB total and change scores. Methods We used individual-level data on participants with Alzheimer’s disease (n=2925) from five pivotal clinical trials of donepezil. Data were collected at baseline and scheduled visits for up to 6 months. We used equipercentile linking to identify the correspondence between simultaneous measurements of MMSE with ADAS-Cog, and SIB total and change ratings. Findings Spearman’s correlation coefficients were of strong magnitude between the MMSE total score and the ADAS-Cog (rs from −0.82 to −0.87; p<0.05) and SIB total scores (rs from 0.70 to 0.75; p<0.05). Weaker correlations between the change scores were observed between the MMSE change score and the ADAS-Cog (week 1: r=−0.11, p=0.18; rs thereafter: −0.28 to −0.45; p<0.05) and SIB change scores (rs from 0.31 to 0.44; p<0.05). Linking suggested that the MMSE total scores were sensitive to moderate and severe cognitive impairment levels. Despite weak to moderate correlations for the change scores, moderate change levels linked well, indicating ceiling and floor effects. Conclusions The current results can be used in meta-analyses, data harmonisation and may contribute to increasing statistical power when pooling data from multiple sources. Clinical implications The current study results help clinicians to understand these cognitive rating scale scores. Data are available upon reasonable request. Data requests can be submitted via .

中文翻译：

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将简易精神状态检查、阿尔茨海默病评估量表-认知分量表和严重损伤电池联系起来：来自五项多奈哌齐随机临床试验的个体参与者数据的证据

背景 简易精神状态检查 (MMSE)、阿尔茨海默病评估量表 - 认知子量表 (ADAS-Cog) 和严重损伤电池 (SIB) 是广泛使用的评估量表，用于评估阿尔茨海默病的认知能力。目的 为了了解这些评分量表之间的对应关系，我们旨在检查 MMSE 与 ADAS-Cog 和 SIB 总分和变化分的联系。方法 我们使用来自多奈哌齐五项关键临床试验的阿尔茨海默病参与者 (n=2925) 的个体数据。数据是在基线时收集的，并安排了长达 6 个月的访问。我们使用等分位链接来确定 ADAS-Cog 的 MMSE 同步测量值与 SIB 总评级和变化评级之间的对应关系。结果 MMSE 总分与 ADAS-Cog（rs 从 -0.82 到 -0.87；p<0.05）和 SIB 总分（rs 从 0.70 到 0.75；p<0.05）之间的 Spearman 相关系数非常大。MMSE 变化评分与 ADAS-Cog（第 1 周：r=-0.11，p=0.18；此后 rs：-0.28 至 -0.45；p<0.05）和 SIB 变化评​​分（rs从 0.31 到 0.44；p<0.05）。关联表明 MMSE 总分对中度和重度认知障碍水平敏感。尽管变化分数的相关性较弱到中等，但中等变化水平相关性良好，表明上限和下限效应。结论 当前的结果可用于荟萃分析、数据协调，并且在汇集多个来源的数据时可能有助于提高统计功效。临床意义 目前的研究结果有助于临床医生了解这些认知评定量表分数。数据可根据合理要求提供。数据请求可以通过以下方式提交。