Background: Post-emetic elevation in thymus and activation-regulated chemokine (TARC) levels has been reported in patients with food protein-induced enterocolitis syndrome (FPIES); however, no studies have investigated differences in TARC levels between FPIES and other diseases. Objectives: We evaluated the clinical usefulness of TARC measurement in differentiating between FPIES and infectious gastroenteritis. Methods: This study included 8 patients with solid-food FPIES (FPIES group; hen’s egg [n = 6], rice [n = 1], and short-neck clam [n = 1]; a total of 11 episodes necessitating emergency department visit or positive result of oral food challenge test) and 17 patients with infectious gastroenteritis (control group), and all patients had no eczema. Post-emetic serum TARC levels and modified TARC levels (serum TARC value – normal mean for each age) were compared between the 2 groups. Results: The median (range) ages for the FPIES and control groups were 0.7 (0.5–6.2) and 1.8 (0.1–4.4) years, respectively (p #x3e; 0.05). In the FPIES and control groups, median (range) TARC levels were 2,911 (1,062–7,816) and 600 (277–2,034) pg/mL, and median (range) modified TARC levels were 2,204 (355–7,109) and 129 (0–1,314), respectively. The TARC and modified TARC levels were significantly higher in the FPIES group than in the control group (p #x3c; 0.001 for both). Conclusion: In the absence of eczema, post-emetic serum TARC levels might be a potential diagnostic biomarker for distinguishing FPIES from infectious gastroenteritis.
Int Arch Allergy Immunol

中文翻译：

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胸腺和活化调节趋化因子鉴别食物蛋白诱发的小肠结肠炎综合征与传染性胃肠炎的诊断准确性评价

背景：据报道，食物蛋白诱导的小肠结肠炎综合征 (FPIES) 患者呕吐后胸腺和活化调节趋化因子 (TARC) 水平升高；然而，没有研究调查 FPIES 与其他疾病之间 TARC 水平的差异。目的：我们评估了 TARC 测量在区分 FPIES 和感染性胃肠炎方面的临床实用性。方法：本研究包括 8 名固体食物 FPIES 患者（FPIES 组；鸡蛋 [ n = 6]、米饭 [ n = 1] 和短颈蛤 [ n= 1]; 共11次急诊或口服食物激发试验阳性）和17例感染性胃肠炎患者（对照组），所有患者均无湿疹。比较两组之间的呕吐后血清 TARC 水平和改良的 TARC 水平（血清 TARC 值 - 每个年龄的正常平均值）。结果： FPIES 和对照组的中位（范围）年龄分别为 0.7 (0.5-6.2) 和 1.8 (0.1-4.4) 岁（p#x3e; 0.05）。在 FPIES 和对照组中，中位（范围）TARC 水平为 2,911 (1,062–7,816) 和 600 (277–2,034) pg/mL，中位（范围）修正 TARC 水平为 2,204 (355–7,109) 和 129 (0 –1,314)，分别。FPIES 组的 TARC 和改良 TARC 水平显着高于对照组（p #x3c；两者均为 0.001）。结论：在没有湿疹的情况下，呕吐后血清 TARC 水平可能是区分 FPIES 和感染性胃肠炎的潜在诊断生物标志物。
Int Arch 过敏免疫