DHX36 is a member of the DExD/H box helicase family, which comprises a large number of proteins involved in various cellular functions. Recently, the function of DHX36 in the regulation of G-quadruplexes (G4s) was demonstrated. G4s are alternative nucleic acid structures, which influence many cellular pathways on a transcriptional and post-transcriptional level. In this review we provide an overview of the current knowledge about DHX36 structure, substrate specificity and mechanism of action based on the available models and crystal structures. Moreover, we outline its multiple functions in cellular homeostasis, immunity, and disease. Finally, we discuss the open questions and provide potential directions for future research.

中文翻译：

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DEAH 解旋酶 DHX36 及其在 G-四链体依赖过程中的作用

DHX36 是 DExD/H 盒解旋酶家族的成员，该家族包含大量参与各种细胞功能的蛋白质。最近，DHX36 在 G-四链体 (G4s) 调控中的功能得到证实。G4s 是替代的核酸结构，它在转录和转录后水平上影响许多细胞途径。在这篇综述中，我们根据可用模型和晶体结构概述了当前关于 DHX36 结构、底物特异性和作用机制的知识。此外，我们概述了它在细胞稳态、免疫和疾病中的多种功能。最后，我们讨论开放性问题并为未来的研究提供潜在的方向。