Interleukin 37 (IL-37) is an anti-inflammatory cytokine involved in the regulation of cholesterol homeostasis, reducing the levels of plasma cholesterol, fatty acids, and triglycerides. The aim of the present study was to evaluate the association of the IL-37 polymorphisms with the presence of hypercholesterolemia (HC), and with cardiovascular risk factors. Nine IL-37 polymorphisms (rs2708965, rs2708962, rs6717710, rs2708961, rs2708960, rs2708958, rs2723187, rs2708947, and rs2723192) were determined by TaqMan assays in a group of 1292 individuals (514 with and 778 without hypercholesterolemia) belonging to the cohort of the GEA Mexican Study. The associations were evaluated by logistic regression, using inheritance models adjusted by confounding variables. Under codominant 1 model, the rs2708961 (OR = 0.51, p = 0.02), rs2723187 (OR = 0.35, p = 0.005), and rs2708947 (OR = 0.49, p = 0.02) polymorphisms were associated with low risk of HC. The association of the polymorphisms with cardiovascular risk factors was evaluated independently in HC and non-HC individuals. In non-HC individuals, some polymorphisms were associated with the risk of having high levels of LDL-C, glucose, and high risk of T2DM, and low risk of having high visceral abdominal fat. On the other hand, in individuals with HC five, polymorphisms were associated with high levels of C-reactive protein. The IL-37 rs2708961, rs2723187, rs2708947 polymorphisms were associated with low risk of HC, and some IL-37 polymorphisms were associated with cardiometabolic factors in both individuals with and without HC.

中文翻译：

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IL-37 基因和胆固醇代谢：多态性与高胆固醇血症和心血管危险因素的关联。GEA 墨西哥研究

白细胞介素 37 ( IL-37 ) 是一种抗炎细胞因子，参与调节胆固醇稳态，降低血浆胆固醇、脂肪酸和甘油三酯的水平。本研究的目的是评估 IL-37 多态性与高胆固醇血症 (HC) 的存在以及心血管危险因素的关联。9 个 IL-37 多态性（rs2708965、rs2708962、rs6717710、rs2708961、rs2708960、rs2708958、rs2723187、rs2708947 和 rs2723 GEA 墨西哥研究。通过逻辑回归评估关联，使用通过混杂变量调整的遗传模型。在共显性 1 模型下，rs2708961 (OR = 0.51,p = 0.02)、rs2723187 (OR = 0.35, p = 0.005) 和 rs2708947 (OR = 0.49, p = 0.02) 多态性与低 HC 风险相关。在 HC 和非 HC 个体中独立评估多态性与心血管危险因素的关联。在非 HC 个体中，一些多态性与高 LDL-C、葡萄糖和高 T2DM 风险以及低内脏腹部脂肪高风险相关。另一方面，在 HC 5 个体中，多态性与高水平的 C 反应蛋白相关。所述IL-37 rs2708961，rs2723187，rs2708947多态性与HC的低风险相关联，以及一些IL-37 在有和没有 HC 的个体中，多态性都与心脏代谢因子相关。