ABSTRACT

Anodisation with electrochemical cathodic deposition method was employed to modify the surface of Ti implants with a bilayer coating made of Sr- doped titania (Sr-TiO₂) and hydroxyapatite doped with magnesium (Mg-HAp). The Mg-HAp/Sr-TiO₂ bilayer coating was compared with pure TiO₂ and Sr-TiO₂ single-layer coating. The Sr incorporation into TiO₂ and Mg substitution into HAp strengthened their bioactive properties. The tensile test indicated increase in the mechanical strength of the bilayer coated substrate compared to pure TiO₂ substrate. Moreover, the study indicated that the Sr and Mg ions were uniformly incorporated into the Mg-HAp/Sr-TiO₂ bilayer coating with significantly higher roughness and hydrophilicity compared to the control. In vitro studies with osteoblasts cells had a superior response to the Mg-HAp/Sr-TiO₂ bilayer surface. It was found that a bilayer Mg-HAp/Sr-TiO₂ coating on Ti implants promotes bioactivity and has superior adhesion strength necessary for osseointegration and bone healing.

摘要

采用电化学阴极沉积方法进行阳极氧化，以改性的Ti植入物表面，该涂层具有Sr掺杂的二氧化钛（Sr-TiO ₂）和镁掺杂的羟基磷灰石（Mg-HAp）制成的双层涂层。将Mg-HAp / Sr-TiO ₂双层涂层与纯TiO ₂和Sr-TiO ₂单层涂层进行比较。Sr掺入TiO ₂和Mg替代HAp增强了它们的生物活性。拉伸试验表明与纯TiO ₂基材相比，双层涂覆的基材的机械强度增加。此外，研究表明，Sr和Mg离子均匀地掺入Mg-HAp / Sr-TiO _2中与对照相比，具有明显更高的粗糙度和亲水性的双层涂层。用成骨细胞进行的体外研究对Mg-HAp / Sr-TiO ₂双层表面有更好的反应。已经发现，Ti植入物上的双层Mg-HAp / Sr-TiO ₂涂层可促进生物活性，并具有骨整合和骨愈合所必需的优异粘附强度。