Abstract The present experiment was conducted to evaluate the effect of enzymatically treated Artemisia annua L. (EA) on intestinal digestive function and immune capacity in weaned pigs. Firstly, a total of 300 21-day-old piglets were randomly allotted to five groups, including CON, EA1, EA2, EA3, and EA4 groups (basal diet supplemented with 0, 0.5, 1, 2, 4 g/kg EA, respectively). At 50 days of age, the results showed that pigs in the EA3 group presented significant improvements (p < .05) of growth performance and health status when compared with those of the CON group. According to the results above, we considered 2 g/kg EA as the optimal dose for pig diets. Therefore, we selected 12 pigs from the CON and EA3 groups (n = 6) at 51 days of age for further investigation in vivo. Compared with the CON group, EA3 group significantly increased (p < .05) small intestinal length of pigs, enhanced (p < .05) the activities of amylase, trypsin and Na+-K+-ATPase and the concentrations of glucose transporter in both jejunum and ileum. EA3 group had lower (p < .05) concentrations of interleukin 1β, interleukin 6 and tumour necrosis factor α in the jejunum and higher (p < .05) concentrations of interleukin 10, secretory immunoglobulin A and immunoglobulin G in the ileum of pigs than the CON group. These results demonstrated that EA provided a dietary nutritional means to improve intestinal function of weaned pigs and 2 g/kg was the optimal dose for weaned pigs in the present study. Highlights Dietary supplementation with 2 g/kg enzymatically treated Artemisia annua L. increased growth performance and nutrient digestibility, decreased the incidence of diarrhoea in weaned pigs. The optimal dose of enzymatically treated Artemisia annua L. in weaned pigs in the current study was 2 g/kg. Enzymatically treated Artemisia annua L. inclusion increased the digestive function of weaned pigs. Diet supplemented with enzymatically treated Artemisia annua L. reduced the inflammation and enhanced the immunity of weaned pigs.

中文翻译：

---

日粮添加酶处理青蒿对断奶仔猪肠道消化功能和免疫力的影响

摘要 本实验旨在评价酶促处理的青蒿（EA）对断奶仔猪肠道消化功能和免疫能力的影响。首先将300头21日龄仔猪随机分为CON组、EA1组、EA2组、EA3组和EA4组（基础日粮添加0、0.5、1、2、4 g/kg EA，分别）。在 50 日龄时，结果表明，与 CON 组相比，EA3 组的猪的生长性能和健康状况有显着改善（p < .05）。根据上述结果，我们认为 2 g/kg EA 作为猪日粮的最佳剂量。因此，我们在 51 日龄时从 CON 和 EA3 组（n = 6）中选择了 12 头猪进行进一步的体内研究。与CON组相比，EA3组显着增加（p < .05）猪的小肠长度，增强（p < .05）淀粉酶、胰蛋白酶和Na+-K+-ATP酶的活性以及空肠和回肠中葡萄糖转运蛋白的浓度。与EA3组相比，EA3组的空肠白细胞介素1β、白细胞介素6和肿瘤坏死因子α的浓度较低（p < .05），而回肠白细胞介素10、分泌性免疫球蛋白A和免疫球蛋白G的浓度较高（p < .05）。 CON组。这些结果表明，EA为改善断奶仔猪肠道功能提供了一种膳食营养手段，本研究中2 g/kg是断奶仔猪的最佳剂量。亮点 含 2 g/kg 酶处理的青蒿的膳食补充剂。提高了生长性能和养分消化率，降低断奶仔猪腹泻的发生率。在目前的研究中，酶处理的青蒿在断奶仔猪中的最佳剂量为 2 g/kg。酶处理的青蒿添加物增加了断奶猪的消化功能。辅以酶处理的青蒿的饮食减少了炎症并增强了断奶猪的免疫力。