The interactions among humans, their environment, and the trillions of microbes residing within the human intestinal tract form a tripartite relationship that is fundamental to the overall health of the host. Disruptions in the delicate balance between the intestinal microbiota and host immunity are implicated in various chronic diseases, including inflammatory bowel disease (IBD). There is no known cure for IBD; therefore, novel therapeutics targeting prevention and symptom management are of great interest. Recently, physical activity in healthy mice was shown to be protective against chemically induced colitis; however, the benefits of physical activity during or following disease onset are not known. In this study, we examine whether voluntary wheel running is protective against primary disease symptoms in a mucin 2-deficient (Muc2^−/−) lifelong model of murine colitis. We show that 6 weeks of wheel running in healthy C57BL/6 mice leads to distinct changes in fecal bacteriome, increased butyrate production, and modulation in colonic gene expression of various cytokines, suggesting an overall primed anti-inflammatory state. However, these physical activity-derived benefits are not present in Muc2^−/− mice harboring a dysfunctional mucosal layer from birth, ultimately showing no improvements in clinical signs. We extrapolate from our findings that while physical activity in healthy individuals may be an important preventative measure against IBD, for those with a compromised intestinal mucosa, a commonality in IBD patients, these benefits are lost.

中文翻译：

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体力活动塑造健康小鼠的肠道微生物群和免疫力，但对 MUC2-/- 小鼠的结肠炎没有保护作用

人类、他们的环境以及居住在人类肠道内的数万亿微生物之间的相互作用形成了三方关系，这对宿主的整体健康至关重要。肠道微生物群和宿主免疫之间微妙平衡的破坏与各种慢性疾病有关，包括炎症性肠病 (IBD)。IBD 没有已知的治愈方法。因此，针对预防和症状管理的新型疗法引起了人们极大的兴趣。最近，健康小鼠的体力活动被证明可以预防化学诱导的结肠炎。然而，在疾病发作期间或之后进行体力活动的益处尚不清楚。在这项研究中，我们检查了在缺乏粘蛋白 2 的情况下，随意跑轮是否可以预防原发性疾病症状。Muc2 ^-/- ) 小鼠结肠炎的终生模型。我们表明，在健康的 C57BL/6 小鼠中运行 6 周的轮子会导致粪便细菌组的明显变化、丁酸产量增加和各种细胞因子结肠基因表达的调节，表明整体处于抗炎状态。然而，这些体力活动衍生的益处在出生时就具有功能失调的粘膜层的Muc2 ^-/-小鼠中不存在，最终临床症状没有改善。我们从我们的研究结果推断，虽然健康个体的体育锻炼可能是预防 IBD 的重要措施，但对于肠黏膜受损的人（IBD 患者的常见问题），这些益处将丧失。