Secondary exposure to e‐cigarette aerosol (passive vaping) will soon become a pressing public health issue in the world. Yet, the current knowledge about respiratory depositions of e‐cigarette aerosol through passive vaping in human airways is limited due to critical weaknesses of traditional experimental methods. To fill in this important knowledge gap, this study proposed a special approach involving an upgraded Mobile Aerosol Lung Deposition Apparatus (MALDA) that consists of a set of human airway replicas including a head airway, tracheobronchial airways down to the 11th lung generation, and a representative alveolar section. In addition to the comprehensive coverage of human airways, the MALDA is easily transportable for providing efficient estimations of aerosol respiratory deposition. In this study, the MALDA was first evaluated in the laboratory and then applied to estimate the respiratory deposition associated with passive vaping in an indoor real‐life setting. The results showed that the respiratory deposition data aligned closely with the conventional respiratory deposition curves not only in the head‐to‐TB region but also in the alveolar region. The strengths of MALDA demonstrate great promise for a wide variety of applications in real‐life settings that could provide crucial information for future public health and indoor air quality studies.

中文翻译：

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通过被动电子烟在人体气道中沉积电子烟气溶胶

二次接触电子烟气溶胶（被动电子烟）将很快成为世界紧迫的公共卫生问题。然而，由于传统实验方法的严重缺陷，目前关于电子烟气溶胶在人体气道中通过被动电子烟沉积的知识有限。为了填补这一重要的知识空白，本研究提出了一种特殊的方法，涉及升级的移动气溶胶肺沉积设备 (MALDA)，该设备由一组人体气道复制品组成，包括头部气道、气管支气管气道直至第 11 代肺，以及代表肺泡切面。除了全面覆盖人体气道外，MALDA 还易于携带，可有效估计气溶胶呼吸道沉积。在这项研究中，MALDA 首先在实验室进行了评估，然后应用于估计与室内现实生活环境中被动吸电子烟相关的呼吸沉积。结果表明，呼吸沉积数据不仅在头-TB区域而且在肺泡区域都与传统的呼吸沉积曲线非常吻合。MALDA 的优势显示出在现实生活环境中的广泛应用前景，可为未来的公共卫生和室内空气质量研究提供重要信息。结果表明，呼吸沉积数据不仅在头-TB区域而且在肺泡区域都与传统的呼吸沉积曲线非常吻合。MALDA 的优势显示出在现实生活环境中的广泛应用前景，可为未来的公共卫生和室内空气质量研究提供重要信息。结果表明，呼吸沉积数据不仅在头-TB区域而且在肺泡区域都与传统的呼吸沉积曲线非常吻合。MALDA 的优势显示出在现实生活环境中的广泛应用前景，可为未来的公共卫生和室内空气质量研究提供重要信息。