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The paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine
Genes & Diseases ( IF 6.9 ) Pub Date : 2020-10-06 , DOI: 10.1016/j.gendis.2020.09.007
Yin Li 1 , Yihan Zhang 1 , Yuhao Zou 1 , Shiwei Duan 1
Affiliation  

MiR-4295, located on chromosome 10q25.2, is a unique miRNA with a wide range of biological functions. miR-4295 is widely expressed in vivo, participating in the biological processes of multiple cancers. Although miR-4295 is dysregulated in various cancers, it has also been found to have the function of inhibiting cancer. At the same time, the expression of miR-4295 is related to prognosis and can be affected by numerous factors connecting to the therapeutic effects of various drugs. This article is to better summarize the role of miR-4295 in cancer and review the potential diagnostic, prognostic, and therapeutic value of miR-4295, which may provide insight into subsequent research.



中文翻译:

miR-4295 在人类癌症中的矛盾作用:在发病机制和个性化医疗中的意义

MiR-4295 位于染色体 10q25.2 上,是一种独特的 miRNA,具有广泛的生物学功能。miR-4295在体内广泛表达,参与多种癌症的生物学过程。虽然 miR-4295 在各种癌症中失调,但也被发现具有抑制癌症的功能。同时,miR-4295 的表达与预后有关,并且会受到与各种药物治疗效果相关的众多因素的影响。本文旨在更好地总结miR-4295在癌症中的作用,回顾miR-4295潜在的诊断、预后和治疗价值,为后续研究提供参考。

更新日期:2020-10-06
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