Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disorders, and cancer. We discuss the emerging signaling crosstalk between UPR stress sensors and the DDR, as well as their involvement in cancer biology.

中文翻译：

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当内质网蛋白稳态遇到 DNA 损伤反应

维持蛋白质组和基因组完整性 (GI) 需要整合广泛的机制和信号通路。这些特别包括未折叠蛋白反应 (UPR) 和 DNA 损伤反应 (DDR)。这些适应机制分别发生在内质网 (ER) 和细胞核中。UPR 和 DDR 的改变与衰老和退行性疾病、代谢和炎症性疾病以及癌症等病理有关。我们讨论了 UPR 压力传感器和 DDR 之间新兴的信号串扰，以及它们在癌症生物学中的参与。