Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue of Structure, Sevy at al. describe a computationally designed cyclic peptide mimicking the CDRH3 loop of the C05 antibody against influenza showing the potential utility of designer biologics.

中文翻译：

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设计师对流感致命弱点的探索

单克隆抗体很有吸引力，但在某些应用中，由于其大尺寸和高特异性，治疗方式有限。在本期结构中，Sevy 等人。描述了一种计算设计的环状肽，它模拟了针对流感的 C05 抗体的 CDRH3 环，显示了设计生物制剂的潜在效用。