This context was investigated to assess the in vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme (ACE) inhibition traits of Punica granatum fruits peel extract. Initially, among various extracts tested, aqueous and ethanolic peel extracts depicted the presence of diverse phytoconstituents. In vitro antioxidative properties of peel extracts were determined using standard methodologies. Results showed that aqueous and ethanolic extracts had IC₅₀ values of 471.7 and 509.16 μg/mL, respectively in terms of 1,1,diphenyl 2,2,picrylhydrazyl scavenging. Likewise, IC₅₀ values of aqueous and ethanol extract were obtained as 488.76 and 478.47 μg/mL towards the degradation of hydrogen peroxide. The ethanolic extract exhibited the highest inhibition of α-glucosidase by showing activity of 53.34 ± 2.0 to 15.18 ± 1.4 U/L in a dose dependent manner (100–1000 µg/mL). Ethanolic extract was reported as the most active inhibitor of lipase with an IC₅₀ value of 603.50 µg/mL. Ethanolic extract showed increased inhibition of ACE in a concentration dependent manner (100–1000 µg/mL) with IC₅₀ value of 519.45 µg/mL. Fourier transform-infrared spectrum revealed the availability of various functional groups in the ethanolic extract of peel. Gas chromatography-mass spectrometry chromatogram of peel extract illustrated 23 diversified chemical constituents including 1,2,3,4-butanetetrol, Dimethyl sulfone, 9-octadecenamide, and Pentadecanoic acid as predominant compounds. In summary, P. granatum fruits peel extract revealed promising antioxidant, anti-diabetic, anti-obesity, and anti-hypertensive properties.

研究该背景以评估石榴果皮提取物的体外抗氧化、抗糖尿病、抗肥胖和血管紧张素转换酶 (ACE) 抑制特性。最初，在测试的各种提取物中，水和乙醇果皮提取物描述了不同植物成分的存在。使用标准方法测定果皮提取物的体外抗氧化特性。结果表明，水提物和乙醇提物对1,1,二苯基2,2,苦基肼清除的IC ₅₀值分别为471.7和509.16 μg/mL。同样，IC ₅₀对于过氧化氢的降解，水提取物和乙醇提取物的值分别为 488.76 和 478.47 μg/mL。乙醇提取物对 α -葡萄糖苷酶的抑制作用最高，活性为 53.34 ± 2.0 至 15.18 ± 1.4 U/L，呈剂量依赖性（100–1000 µg/mL）。据报道，乙醇提取物是最有效的脂肪酶抑制剂，其 IC ₅₀值为 603.50 µg/mL。乙醇提取物以浓度依赖性方式 (100–1000 µg/mL) 显示出对 ACE 的抑制增加，IC ₅₀值为 519.45 µg/mL。傅里叶变换红外光谱揭示了果皮乙醇提取物中各种官能团的可用性。果皮提取物的气相色谱-质谱色谱图显示了 23 种不同的化学成分，包括 1,2,3,4-丁四醇、二甲基砜、9-十八烯酰胺和十五烷酸作为主要化合物。总之，P. granatum果实果皮提取物显示出有前景的抗氧化、抗糖尿病、抗肥胖和抗高血压特性。