The telencephalon of adult mammals shows constitutive neurogenesis, and disease or traumatic injuries alter the rate of neurogenesis in the adult brain. Understanding the molecular signals that control adult brain neurogenesis is of crucial importance for the development of therapies to promote regeneration in the injured or diseased brain. Here, I reviewed our current knowledge on the role of cyclooxygenases and prostaglandins in controlling adult brain neurogenesis. Current data indicate that cyclooxygenase-2 derived prostaglandin E₂ acting through EP receptors promotes neurogenesis in adult neurogenic niches of the telencephalon and that manipulations of this signalling pathway could be used to promote neurogenesis under pathological conditions. In this review article, I also propose new research directions to increase our knowledge on the role of this signalling pathway in neurogenesis.

成年哺乳动物的端脑显示出组成性神经发生，疾病或创伤会改变成年大脑中神经发生的速率。了解控制成人大脑神经发生的分子信号对于开发促进受伤或患病大脑再生的疗法至关重要。在这里，我回顾了我们目前关于环氧合酶和前列腺素在控制成人大脑神经发生中的作用的知识。目前的数据表明，环氧合酶-2衍生的前列腺素E ₂通过EP受体发挥作用，促进成人端脑神经源性微环境中的神经发生，并且对该信号通路的操作可用于促进病理条件下的神经发生。在这篇综述文章中，我还提出了新的研究方向，以增加我们对该信号通路在神经发生中的作用的了解。