Dopamine has a crucial and well-documented role in the development and maintenance of Gambling Disorder (GD). This systematic review adopts a translational approach aimed at providing a comprehensive synthesis of current clinical and preclinical knowledge on dopaminergic function in GD at a neurobiological level. To this end, we present and discuss converging dopaminergic alterations and phenotypes. Preclinical and clinical review protocols were registered on the PROSPERO database (CRD42019124404, CRD42019124405). The literature search was conducted in accordance with PRISMA guidelines using three databases (PubMed, Web of Science, Scopus). We identified 67 preclinical studies using pharmacological and non-pharmacological manipulations of the gambling-like phenotype and 33 human studies investigating either genetic polymorphisms or functional brain imaging data. Dopamine transporter and D2, D3, D4 receptor alterations showed strongest translational concordance. Though no postsynaptic dopaminergic alterations were observed, several studies point at dysfunctions in presynaptic dopamine trafficking in GD, suggestive of hyperdopaminergic states. Developing meaningful translational models is essential to working towards the development of an integrated conceptual framework for GD and neurobiologically-based treatment interventions.

多巴胺在赌博疾病（GD）的发展和维持中起着至关重要的，有据可查的作用。该系统评价采用了一种翻译方法，旨在提供神经生物学水平上有关GD中多巴胺能功能的当前临床和临床前知识的全面综合。为此，我们提出并讨论会聚的多巴胺能改变和表型。临床前和临床审查方案已在PROSPERO数据库（CRD42019124404，CRD42019124405）中注册。文献检索是根据PRISMA指南使用三个数据库（PubMed，Web of Science，Scopus）进行的。我们确定了67种临床前研究，其中使用了赌博样表型的药理和非药理学操作，另外还有33项研究了遗传多态性或功能性脑成像数据的人体研究。多巴胺转运蛋白和D2，D3，D4受体的变化表现出最强的翻译一致性。尽管没有观察到突触后多巴胺能的改变，但有几项研究指出了GD中突触前多巴胺转运的功能障碍，提示多巴胺能亢进状态。开发有意义的翻译模型对于致力于为GD和基于神经生物学的治疗干预措施的综合概念框架的开发至关重要。尽管没有观察到突触后多巴胺能的改变，但有几项研究指出了GD中突触前多巴胺转运的功能障碍，提示多巴胺能亢进状态。开发有意义的翻译模型对于致力于为GD和基于神经生物学的治疗干预措施的综合概念框架的开发至关重要。尽管没有观察到突触后多巴胺能的改变，但有几项研究指出了GD中突触前多巴胺转运的功能障碍，提示多巴胺能亢进状态。开发有意义的翻译模型对于致力于为GD和基于神经生物学的治疗干预措施的综合概念框架的开发至关重要。