TAM family tyrosine kinase receptors including Tyro3, Axl, and MerTK are the key efferocytosis receptors presenting on antigen-presenting cell that mediate the clearance of apoptotic cells. They are thought to regulate inflammatory diseases by modulating inflammatory response and efferocytosis. Recent studies have revealed novel roles of TAM receptors in the biosynthesis of specialized pro-resolving mediators (SPMs) and inflammation resolution. In this chapter, we discuss the central roles of TAM signaling in atherosclerosis focusing on their regulation in efferocytosis and inflammation resolution and highlight the unique therapeutic potential of SPMs in blocking the progression of atherosclerosis.

TAM 家族酪氨酸激酶受体，包括 Tyro3、Axl 和 MerTK，是介导凋亡细胞清除的抗原呈递细胞上呈递的关键胞吞作用受体。它们被认为通过调节炎症反应和胞吞作用来调节炎症性疾病。最近的研究揭示了 TAM 受体在专门的促消退介质 (SPM) 和炎症消退的生物合成中的新作用。在本章中，我们讨论了 TAM 信号在动脉粥样硬化中的核心作用，重点是它们在胞吐作用和炎症消退中的调节，并强调了 SPM 在阻止动脉粥样硬化进展方面的独特治疗潜力。