OBJECTIVE To evaluate the effect of testosterone treatment on metabolic and inflammation parameters and leukocyte-endothelium interactions in transgender men (TGM). DESIGN Prospective observational study. SETTING University hospital. PATIENT(S) One hundred fifty-seven TGM. INTERVENTION(S) Administration of testosterone undecanoate (1,000 mg, intramuscular) every 12 weeks. MAIN OUTCOME MEASURE(S) Endocrine parameters, adhesion molecules (vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, and E-selectin), proinflammatory cytokines interleukin-6, and tumor necrosis factor alpha were evaluated in serum before and after treatment using Luminex's xMAP technology. In addition, interactions between human umbilical vein endothelial cells and polymorphonuclear leukocytes were assessed by flow chamber microscopy. RESULT(S) Testosterone treatment led to an increase in leukocyte-endothelium interactions due to an increase in polymorphonuclear leukocytes rolling and adhesion and decreased rolling velocity. It also boosted levels of vascular cell adhesion molecule-1, E-selectin, interleukin-6, and tumor necrosis factor alpha. As expected, testosterone also produced a significant increase in free androgenic index, androstenedione, total testosterone, and atherogenic index of plasma and a decrease in sex hormone-binding globulin and high-density lipoprotein cholesterol. CONCLUSION(S) Treatment of TGM with testosterone induces an increase in leukocyte-endothelium interactions and adhesion molecules and proinflammatory cytokines. These effects are a reason to monitor cardiovascular risk in these patients.

中文翻译：

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睾酮给药增加了跨性别男性的白细胞-内皮相互作用和炎症

目的 评估睾酮治疗对跨性别男性 (TGM) 代谢和炎症参数以及白细胞-内皮相互作用的影响。设计前瞻性观察研究。设置大学医院。患者（S）一百五十七 TGM。干预措施 每 12 周给予十一酸睾酮（1,000 毫克，肌肉注射）。主要观察指标在血清中评估内分泌参数、粘附分子（血管细胞粘附分子 1、细胞间细胞粘附分子 1 和 E-选择素）、促炎细胞因子白细胞介素 6 和肿瘤坏死因子 α 前后使用 Luminex 的 xMAP 技术进行治疗。此外，人脐静脉内皮细胞和多形核白细胞之间的相互作用通过流室显微镜进行评估。结果 由于多形核白细胞滚动和粘附增加以及滚动速度降低，睾酮治疗导致白细胞-内皮相互作用增加。它还提高了血管细胞粘附分子 1、E-选择素、白细胞介素 6 和肿瘤坏死因子 α 的水平。正如预期的那样，睾酮还显着增加了游离雄激素指数、雄烯二酮、总睾酮和血浆致动脉粥样硬化指数，并降低了性激素结合球蛋白和高密度脂蛋白胆固醇。结论 (S) 用睾酮治疗 TGM 会诱导白细胞-内皮相互作用和粘附分子以及促炎细胞因子的增加。这些影响是监测这些患者心血管风险的一个原因。