The nuclear pore membrane protein 121 (POM121) is an important member of the nuclear pore complex which regulates nucleocytoplasmic transport, but little is known about the role of POM121 in laryngeal cancer. In this study, quantitative real-time polymerase chain reaction and immunohistochemistry were performed to detect POM121 expression in laryngeal tissues. The associations between POM121 and clinicopathological characteristics and overall survival in laryngocarcinoma patients were also analyzed. The mechanism of POM121 was preliminarily explored through gene set enrichment analysis (GSEA). mRNA and protein expression of POM121 in laryngocarcinoma tissues were higher than those in nontumor tissues. High POM121 expression was positively correlated with poor differentiation (χ²=42.391, P<0.001), advanced distant metastases (χ²=20.346, P<0.001) and TNM stage (χ²=23.436, P<0.001). Laryngocarcinoma patients with high POM121 level tended to have poor overall survival. GSEA confirmed that the mechanism of POM121 in laryngeal cancer may relate to sphingolipid metabolism, lysosome, fatty acid metabolism, ribosome, nucleotide excision repair and the PPAR signaling pathway. Overall, POM121 expression might be a prognostic biomarker in laryngeal cancer, and POM121 has the potential to present as a therapeutic target for laryngocarcinoma patients.

中文翻译：

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POM121是预测喉癌预后的新型标志物。

核孔膜蛋白 121 (POM121) 是调节核质转运的核孔复合体的重要成员，但对 POM121 在喉癌中的作用知之甚少。在这项研究中，进行定量实时聚合酶链反应和免疫组织化学以检测喉组织中 POM121 的表达。还分析了 POM121 与喉癌患者临床病理特征和总生存率之间的关联。通过基因集富集分析（GSEA）初步探讨了POM121的作用机制。POM121在喉癌组织中的mRNA和蛋白表达高于非肿瘤组织。POM121高表达与分化差（χ²=42.391，P<0.001）、晚期远处转移（χ²=20.346，P<0.001）呈正相关。001) 和 TNM 分期 (χ²=23.436, P<0.001)。具有高 POM121 水平的喉癌患者的总体生存率往往较差。GSEA证实POM121在喉癌中的作用机制可能与鞘脂代谢、溶酶体、脂肪酸代谢、核糖体、核苷酸切除修复和PPAR信号通路有关。总体而言，POM121 表达可能是喉癌预后的生物标志物，并且 POM121 有可能成为喉癌患者的治疗靶点。