1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) as a highly efficient bicyclic amidine catalyst promoted one-pot multi-component synthesis of biologically active 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile under solvent-free conditions through simple filter with no necessity of chromatographic purification steps. Use of safe, non-volatile, non-corrosive, highly efficient, readily available and easy to handle of catalyst, one-pot reaction, high yields and short reaction times, economical and convenient synthesis, solvent-free conditions and operational simplicity are among the other added advantages that make this approach an attractive alternative for the synthesis of these biologically active compounds.

中文翻译：

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1,8-二氮杂双环[5.4.0]十一碳-7-烯（DBU）：作为高效的双环am催化剂，可促进无溶剂和一锅法合成1H-吡唑并[1，2-b]酞嗪-5， 10-二酮衍生物

1,8-二氮杂双环[5.4.0]十一烷基-7-烯（DBU）作为高效的双环am催化剂促进了生物活性的1 H-吡唑并[1，2-b]酞嗪-5的一锅多组分合成。，10-二酮衍生物通过通过简单的过滤器，无需色谱纯化步骤，即可在无溶剂条件下将邻苯二甲酰亚胺，一水合肼，芳基醛和丙二腈进行一锅四组分缩合反应。使用安全，不挥发，不腐蚀，高效，易于获得且易于处理的催化剂，一锅反应，高收率和短反应时间，经济方便的合成，无溶剂条件和操作简便等其他优点使该方法成为合成这些生物活性化合物的有吸引力的替代方法。