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Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2021-12-01 , DOI: 10.1136/bjophthalmol-2020-317478
Kunihiko Akino 1 , Norihiro Nagai 1, 2 , Kazuhiro Watanabe 1 , Norimitsu Ban 1 , Toshihide Kurihara 1 , Atsuro Uchida 1 , Hajime Shinoda 1 , Kazuo Tsubota 1 , Yoko Ozawa 2, 3, 4, 5
Affiliation  

Background/Aims Pars plana vitrectomy (PPV) is widely performed in patients with idiopathic epiretinal membrane (iERM) to improve vision. Postoperative visual field defects (VFDs) have been previously reported. However, whether they occur when using the most recent PPV system, and the frequency of VFDs as measured by standard automated perimetry, remain poorly documented and were examined in this study. Methods Data of 30 eyes (30 patients; mean age, 66.1 years; 15 men) who underwent PPV for iERM during February 2016–June 2019 and had preoperative and postoperative visual field measurements using standard automated perimetry (Humphrey visual field analyser 30-2 program) were retrospectively analysed. Eyes with diseases other than iERM, including moderate-to-severe cataract or preoperative VFDs were excluded. Results VFD, defined by the Anderson and Patella’s criteria, was found in 73.3% of the eyes 1 month after PPV. After age adjustment, internal limiting membrane (ILM) peeling was identified as a risk factor for postoperative VFD (p=0.035; 95% CI 1.173 to 92.8). Postoperative VFD was frequently observed nasally (86.4%, p=0.002), and on optical coherence tomography measurements, ganglion cell layer (GCL) thinning was found temporal to the fovea (p=0.008). Thinning of the superior and inferior retinal nerve fibre layers and of the GCL temporal to the fovea were significant in eyes after ILM peeling (all p<0.05). Conclusion ILM peeling may cause inner retinal degeneration and lead to the development of VFDs after PPV, which should be further examined.

中文翻译:

特发性视网膜前膜平坦部玻璃体切除术后新发视野缺损和神经退行性变的风险

背景/目的 平坦部玻璃体切除术 (PPV) 广泛用于特发性视网膜前膜 (iERM) 患者以改善视力。以前曾报道过术后视野缺损 (VFD)。然而,它们是否在使用最新的 PPV 系统时发生,以及通过标准自动视野测量法测量的 VFD 的频率,仍然没有得到很好的记录,并在本研究中进行了检查。方法 30 只眼(30 名患者;平均年龄 66.1 岁;15 名男性)的数据,他们在 2016 年 2 月至 2019 年 6 月期间接受了 iERM 的 PPV,并使用标准自动视野测量仪(Humphrey 视野分析仪 30-2 程序)进行了术前和术后视野测量) 进行了回顾性分析。排除 iERM 以外疾病的眼睛,包括中度至重度白内障或术前 VFD。结果 VFD,根据 Anderson 和 Patella 标准定义,PPV 后 1 个月在 73.3% 的眼睛中发现。年龄调整后,内界膜 (ILM) 剥离被确定为术后 VFD 的危险因素(p=0.035;95% CI 1.173 至 92.8)。术后 VFD 经常在鼻腔观察到(86.4%,p=0.002),在光学相干断层扫描测量中,发现中央凹颞侧神经节细胞层(GCL)变薄(p=0.008)。ILM剥离后,上、下视网膜神经纤维层和中央凹颞侧GCL变薄显着(均p<0.05)。结论 ILM剥离可能引起内层视网膜变性并导致PPV后发生VFD,应进一步研究。内界膜 (ILM) 剥离被确定为术后 VFD 的危险因素(p=0.035;95% CI 1.173 至 92.8)。术后 VFD 经常在鼻腔观察到(86.4%,p=0.002),在光学相干断层扫描测量中,发现中央凹颞侧神经节细胞层(GCL)变薄(p=0.008)。ILM剥离后,上、下视网膜神经纤维层和中央凹颞侧GCL变薄显着(均p<0.05)。结论 ILM剥离可能引起内层视网膜变性并导致PPV后发生VFD,应进一步研究。内界膜 (ILM) 剥离被确定为术后 VFD 的危险因素(p=0.035;95% CI 1.173 至 92.8)。术后 VFD 经常在鼻腔观察到(86.4%,p=0.002),在光学相干断层扫描测量中,发现中央凹颞侧神经节细胞层(GCL)变薄(p=0.008)。ILM剥离后,上、下视网膜神经纤维层和中央凹颞侧GCL变薄显着(均p<0.05)。结论 ILM剥离可能引起内层视网膜变性并导致PPV后发生VFD,应进一步研究。发现神经节细胞层(GCL)变薄位于中央凹的时间(p = 0.008)。ILM剥离后,上、下视网膜神经纤维层和中央凹颞侧GCL变薄显着(均p<0.05)。结论 ILM剥离可能引起内层视网膜变性并导致PPV后发生VFD,应进一步研究。发现神经节细胞层(GCL)变薄位于中央凹的时间(p = 0.008)。ILM剥离后,上、下视网膜神经纤维层和中央凹颞侧GCL变薄显着(均p<0.05)。结论 ILM剥离可能引起内层视网膜变性并导致PPV后发生VFD,应进一步研究。
更新日期:2021-11-25
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