Background and Purpose. The main goal of the study was to assess the usefulness of plasma concentrations of catestatin as a predictor of a composite endpoint (CE): unplanned hospitalization and death for all causes in patients with HFrEF in the midterm follow-up. Experimental Approach. The study group consisted of 52 Caucasian patients in NYHA classes II and III. The control group consisted of 24 healthy volunteers. The biomarkers, whose concentration was assessed before and after physical exertion as well as the variability of their concentration under the influence of the physical exertion, were NT-proBNP, troponin T, and catestatin. Key Results. During the 24-month follow-up period, 11 endpoints were recorded. The univariate analysis of the Cox proportional hazard model showed a statistically significant effect of all assessed CST concentrations on the occurrence of CE. In the 24-month follow-up, where the starting concentration of catestatin was compared with other recognized prognostic factors in HF, the initial concentration of catestatin showed statistical significance in CE prognosis as the only parameter tested. Conclusions. Plasma concentration of catestatin before and after physical exertion is a valuable prognostic parameter in predicting death from all causes and unplanned hospitalization in the group of patients with HFrEF in the 2-year follow-up.

中文翻译：

---

Catestatin作为稳定的心力衰竭患者的新的预后标志物，两年随访

背景和目的。这项研究的主要目的是评估血浆Catestatin浓度作为复合终点（CE）的预测指标的有效性：中期随访中HFrEF患者的所有原因的计划外住院和死亡。实验方法。该研究组由52名NYHA II级和III级白种人患者组成。对照组由24名健康志愿者组成。生物标志物是NT-proBNP，肌钙蛋白T和catestatin，其在体育锻炼之前和之后的浓度以及在体育锻炼的影响下其浓度的变化均被评估。关键结果。在24个月的随访期内，记录了11个终点。Cox比例风险模型的单变量分析显示，所有评估的CST浓度对CE发生的影响具有统计学意义。在24个月的随访中，将catestatin的起始浓度与HF中其他公认的预后因素进行了比较，catestatin的初始浓度在CE预后中显示出统计学意义，是唯一测试的参数。结论。在2年的随访中，HFrEF患者组中体育锻炼前后的血浆他汀类药物浓度是预测所有原因死亡和计划外住院的重要预后参数。