There is a well-established relationship between cannabis use and psychosis, although the exact nature of this relationship is not fully understood. Recent studies have observed significant genetic overlap between a diagnosis of schizophrenia and lifetime cannabis use. Expanding on this work, the current study aimed to examine whether genetic overlap also occurs for subclinical psychosis (schizotypy) and cannabis use, as well as examining the phenotypic association between the traits. Phenotypic correlations were calculated for a variety of schizotypy and cannabis phenotypes in the UK Biobank (UKB), and single nucleotide polymorphism (SNP)-based heritability estimates and genetic correlations were calculated for these UKB phenotypes as well as for several other variables taken from recent genomewide association studies. Positive phenotypic correlations were observed between 11 out of 12 pairs of the cannabis use and schizotypy phenotypes (correlation range .05–.18), indicating a robust association between increased symptoms of schizotypy and cannabis use. SNP-based heritability estimates for two schizotypy phenotypes remained significant after multiple testing correction: social anhedonia (h2SNP = .08, SE = .02, N = 4025) and ever seen an unreal vision (h2SNP = .35, SE = .10, N = 150,717). Finally, one significant genetic correlation was observed between schizotypy and cannabis use, a negative correlation between social anhedonia and number of times used cannabis (rg = −.30, p = .012). The current study suggests the relationship between cannabis use and psychosis is also seen in subclinical symptoms of psychosis, but further research with larger samples is needed to determine the biological mechanisms underlying this association.

大麻使用与精神病之间有一种公认的关系，尽管这种关系的确切性质尚未得到充分了解。最近的研究已经观察到精神分裂症的诊断和终生大麻使用之间的显着遗传重叠。在这项工作的基础上，当前的研究旨在检查亚临床精神病（精神分裂症）和大麻的使用是否也发生了遗传重叠，以及研究这些性状之间的表型关联。计算了英国生物库（UKB）中各种精神分裂症和大麻表型的表型相关性，并且基于单核苷酸多态性（SNP）的遗传力估计值和遗传相关性针对这些UKB表型以及从最近的一些其他变量中计算得出全基因组关联研究。在12对大麻使用中的11对与精神分裂症表型之间观察到正表型相关性（相关范围为.05–.18），表明精神分裂症症状增加和大麻使用之间有很强的联系。经过多次测试校正后，两种精神分裂症表型的基于SNP的遗传力估计仍然很重要：社交性快感不足（h 2 SNP = .08，SE = .02，N = 4025），并且从未见过虚幻的视力（h 2 SNP = .35，SE = .10，N = 150,717）。最后，schizotypy和大麻的使用，存在负相关关系之间观察到一个显著遗传相关性社会快感缺乏和次数使用大麻（ř克= -.30，p= .012）。当前的研究表明，在亚临床精神病症状中也可以看到大麻使用与精神病之间的关系，但是需要进一步的研究以更大的样本来确定这种关联的生物学机制。