Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox states of blood using a point-of-care NMR system. Various redox states of the hemoglobin were mapped out using the newly proposed (pseudo) two-dimensional map known as T₁–T₂ magnetic state diagram. We exploit the fact that oxidative stress changes the subtle molecular motion of water proton in the blood, and thus inducing a measurable shift in magnetic resonance relaxation properties. We demonstrated the clinical utilities of this technique to rapidly stratify diabetes subjects based on their oxidative status in conjunction to the traditional glycemic level to improve the patient stratification and thus the overall outcome of clinical diabetes care and management.

糖尿病是全球增长最快的健康负担之一。氧化应激与糖尿病并发症（例如心血管事件）的发病机制有关，但人们对氧化应激仍知之甚少。我们报告了一种使用即时核磁共振系统快速操纵和评估血液氧化还原状态的新方法。使用新提出的（伪）二维图（称为T ₁ – T ₂磁状态图）绘制了血红蛋白的各种氧化还原状态。我们利用氧化应激改变血液中水质子的微妙分子运动这一事实，从而诱导磁共振弛豫特性发生可测量的变化。我们展示了该技术的临床实用性，可以根据糖尿病受试者的氧化状态结合传统的血糖水平对糖尿病受试者进行快速分层，以改善患者分层，从而改善临床糖尿病护理和管理的总体结果。