ABSTRACT

Acetylation of histone and non-histone proteins is a post-translational modification mostly associated with activation of gene transcription. The first histone acetyltransferase (HAT) identified as modifying newly synthesized histone H4 in yeast was a type B HAT named HAT1. Although it was the first HAT to be discovered, HAT1 remains one of the most poorly studied enzymes in its class. In addition to its well-established role in the cytoplasm, recent findings have revealed new and intriguing aspects of the function of HAT1 in the nucleus. Several studies have described its involvement in regulating different pathways associated with a wide range of diseases, including cancer. This review focuses on our current understanding of HAT1, highlighting its importance in regulating chromatin replication and gene expression. This previously unknown role for HAT1 opens up novel scenarios in which further studies will be required to better understand its function.

摘要

组蛋白和非组蛋白的乙酰化是一种翻译后修饰，主要与基因转录的激活有关。第一个被鉴定为修饰酵母中新合成的组蛋白 H4 的组蛋白乙酰转移酶 (HAT) 是一种名为HAT1的 B 型 HAT 。尽管它是第一个被发现的 HAT，但 HAT1 仍然是同类酶中研究最少的酶之一。除了在细胞质中已确立的作用外，最近的研究结果还揭示了 HAT1 在细胞核中功能的新的和有趣的方面。几项研究描述了它参与调节与包括癌症在内的多种疾病相关的不同途径。这篇评论的重点是我们目前对HAT1的理解，强调其在调节染色质复制和基因表达中的重要性。HAT1以前未知的角色开辟了新的场景，需要进一步研究以更好地了解其功能。