ABSTRACT

Formal occupational exposure limits (OELs) for polyalphaolefin (PAO) fluids have not been proposed. Specific PAO fluids are utilized as aircraft hydraulics or heat sink coolants for electronics and aircraft service air. Toxicity was compared for a PAO fluid in male and female Fischer 344 rats using acute inhalation (0, 100, 500, or 1000 mg/m³ aerosol for 6 hr) and two-week inhalation (0, 20, 100, or 300 mg/m³ aerosol for 6 hr/day, 5 days/week) studies. Neurobehavioral tests following acute exposure showed that both genders were less responsive after exposure to 1000 mg/m³ PAO, and to a lesser extent following 500 mg/m³ PAO. Body weight, food, and water consumption were also affected with recovery after 24 hr. Histopathology for the acute group demonstrated an exposure response increase in severity (minimal to mild) of lesions in the posterior nasal cavities and lungs. Severity of lesions was reduced in the recovery groups (normal to minimal). Acute effects were short-lived and recoverable. Following the two-week exposure, effects were limited to lesions only in the posterior nasal cavities and lungs of the high exposure group, with less severity than in the acute exposure high concentration group. Short-term repeated exposure did not result in any cumulative effects except for minimal respiratory tract changes in the 300 mg/m³ exposure group. Data-driven operational exposure limits (OpELs) were proposed based upon Acute Exposure Guideline Levels process resulting in values of 28, 28, 14, 3.5, and 1.7 mg/m³ for 10 and 30 min, 1, 4, and 8 hr, respectively.

摘要

尚未提出聚α烯烃（PAO）流体的正式职业接触限值（OEL）。特定的PAO流体可用作飞机液压系统或电子设备和飞机维修空气的散热器冷却剂。使用急性吸入（0、100、500或1000 mg / m ³气雾剂持续6小时）和两周吸入（0、20、100或300 mg）比较雄性和雌性Fischer 344大鼠的PAO液的毒性/ m ³气雾剂，每天6小时，5天/周）。急性暴露后的神经行为测试表明，两种性别在暴露于1000 mg / m ³ PAO后的反应较慢，而在500 mg / m ³ PAO之后的反应较小AO 体重，食物和水的消耗也受到24小时恢复的影响。急性组的组织病理学表明，后鼻腔和肺部病变的暴露反应严重程度（最小至轻度）增加。恢复组的病变严重程度降低（正常至最小）。急性作用是短暂的且可恢复的。在两周的暴露后，仅在高暴露组的鼻后腔和肺部病变受到影响，严重程度低于急性高暴露组。短期重复接触不会产生任何累积效应，除了300 mg / m ^3的最小呼吸道变化外暴露组。根据急性暴露指导水平程序提出了数据驱动的操作暴露极限（OpEL），得出10、30分钟，1、4和8小时的值为28、28、14、3.5和1.7 mg / m ³，分别。