ABSTRACT

Introduction

Urinary tract infections (UTIs) are usual diseases caused by different strains of microorganisms. Many antibiotics have been applied for the treatment of these infections. However, the development of multidrug-resistant strains is a major problem in these treatments. As alternative complementary agents, several medicinal plants are often used to prevent and/or treat these diseases.

Areas covered

This review summarized the current evidence about the efficacy of medicinal plants’ consumption to prevent and/or co-treat UTIs. The most precise scientific databases, e.g. Medline, Scopus, and Web of Science were comprehensively searched, using relative keywords to identify the relative in vivo and ex vivo animal and human studies.

Expert opinion

Current studies supported evidence for potential benefit overall concerning medicinal plants’ consumption against UTIs by preventing bacterial adherence and inhibiting inflammation cascades through responding immunologically to bacteria invasion. However, most of the current evidence have been focused on in vivo and ex vivo animal studies, while human studies are currently limited and did not focus on a specific medicinal plant. Thus, well-designed clinical trials for long study periods focused on individual medicinal plants are intensely recommended to delineate their effectiveness on the prevention and/or co-treatment of UTIs.

中文翻译：

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对尿路感染的药用植物消费：对当前证据的叙述性审查

摘要

介绍

尿路感染 (UTI) 是由不同菌株的微生物引起的常见疾病。许多抗生素已被用于治疗这些感染。然而，多重耐药菌株的发展是这些治疗中的一个主要问题。作为替代补充剂，通常使用几种药用植物来预防和/或治疗这些疾病。

覆盖区域

本综述总结了有关食用药用植物预防和/或共同治疗 UTI 功效的当前证据。对最精确的科学数据库，例如 Medline、Scopus 和 Web of Science 进行了全面搜索，使用相关关键字来确定相关的体内和体外动物和人类研究。

专家意见

目前的研究支持了关于药用植物消耗对 UTI 的潜在益处的证据，通过防止细菌粘附和通过对细菌入侵的免疫反应来抑制炎症级联反应。然而，目前的大多数证据都集中在体内和体外动物研究上，而人类研究目前有限，并没有关注特定的药用植物。因此，强烈建议针对单个药用植物进行精心设计的长期研究临床试验，以描述它们在预防和/或联合治疗 UTI 方面的有效性。