Emerging insights on the role of gasdermins in infection and inflammatory diseases,Clinical & Translational Immunology

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Emerging insights on the role of gasdermins in infection and inflammatory diseases
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-10-04 , DOI: 10.1002/cti2.1186
Lipeng Tang _{1,

2} , Chuanjian Lu ₃ , Guangjuan Zheng _{1,

4} , Boudewijn MT Burgering ₂

Affiliation

The gasdermins, family of pore‐forming proteins, are emerging key regulators of infection, autoinflammation and antitumor immunity. Multiple studies have recently characterised their crucial roles in driving pyroptosis, a lytic pro‐inflammatory type of cell death. Additionally, gasdermins also act as key effectors of NETosis, secondary necrosis and apoptosis. In this review, we will address current understanding of the mechanisms of gasdermin activation and further describe the protective and detrimental roles of gasdermins in host defence and autoinflammatory diseases. These data suggest that gasdermins play a prominent role in innate immunity and autoinflammatory disorders, thereby providing potential new therapeutic avenues for the treatment of infection and autoimmune disease.

中文翻译：

关于胃泌素在感染和炎症性疾病中作用的新兴见解

Gasdermins是造孔蛋白家族，是感染，自发炎症和抗肿瘤免疫的新兴关键调节剂。最近的多项研究表明了它们在驱动细胞凋亡中的关键作用，该细胞凋亡是一种裂解性促炎性细胞死亡。另外，胃泌素还充当NETosis，继发性坏死和细胞凋亡的关键效应物。在这篇综述中，我们将介绍对加德明激活机制的当前了解，并进一步描述加德明在宿主防御和自发性疾病中的保护作用和有害作用。这些数据表明，胃泌素在先天免疫和自身炎症性疾病中起着重要作用，从而为治疗感染和自身免疫性疾病提供了潜在的新治疗途径。

更新日期：2020-10-05

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