Amphiphilic Functionalized Oligomers: A Promising Strategy for the Postfabrication Functionalization of Liposomes,Advanced Materials Interfaces

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Amphiphilic Functionalized Oligomers: A Promising Strategy for the Postfabrication Functionalization of Liposomes
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2020-10-05 , DOI: 10.1002/admi.202001168
Christian Wölk _{1,

2} , Hafiz Awais Nawaz _{1,

3} , Iram Maqsood ₁ , Fabio Strati ₄ , Gerald Brezesinski ₄ , Gerd Hause ₅ , Michaela Schulz‐Siegmund ₁ , Michael C. Hacker _{1,

6}

Affiliation

Liposomes are promising drug carriers already used in clinical practice, but feasible methods for surface modifications are needed to enhance the application spectrum. This work describes the establishment of the first representative of amphiphilic functionalized oligomers as universal tool for the tuning of liposome characteristics based on a flexible building block strategy. The oligomer binds to liposomes composed of different lipids and modifies the surface characteristics. The charge of neutrally and even negatively charged liposomes is switched to a positive surface charge by grafting liposomes with the novel oligomer to create hybrid vesicles while integrity and structure of liposomes is not affected. The role of the alkyl chain anchors of the oligomer as driving force for formation of hybrid vesicles is demonstrated. The oligomer modification of liposomes is utilized to enhance the biological behavior of the vesicles demonstrated by an enhanced uptake in fibroblasts.

中文翻译：

两亲功能化的低聚物：脂质体的后加工功能化的有前途的策略。

脂质体是已经在临床实践中使用的有希望的药物载体，但是需要表面修饰的可行方法以增强应用范围。这项工作描述了两亲功能化的低聚物的第一个代表的建立，作为基于灵活构件策略调整脂质体特性的通用工具。低聚物与由不同脂质组成的脂质体结合并修饰表面特性。通过将脂质体与新型低聚物接枝以生成杂化囊泡，可将中性甚至带负电荷的脂质体的电荷转换为正表面电荷，而不会影响脂质体的完整性和结构。证明了低聚物的烷基链锚作为形成杂化囊泡的驱动力的作用。

更新日期：2020-11-21

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