Cover story

Our cover features an H&E staining of spinal cord of control (Sirpaf/f) mice with myelin oligodendrocyte glycoprotein (MOG)‐induced experimental autoimmune encephalomyelitis (EAE). The image is taken from Nishimura et al. (pp. 1560–1570), where the authors present the infiltration of mononuclear cells around blood vessels 20 days after immunization with MOG peptide is markedly attenuated in mice, in which SIRPα is specifically ablated in CD11c⁺ cells. The study provides novel insights into the mechanism of SIRPα on dendritic cells in the priming of self‐reactive Th17 cells in draining LNs during disease induction, as well as in the infiltration or reactivation of Th17 cells in the CNS at the disease peak. The original image was digitally modified for the cover.

中文翻译：

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封面故事

我们的封面介绍了髓鞘少突胶质细胞糖蛋白（MOG）诱导的实验性自身免疫性脑脊髓炎（EAE）对对照（Sirpaf / f）小鼠脊髓的H＆E染色。该图像取自Nishimura等人。（pp。1560–1570），作者提出用MOG肽免疫后20天，小鼠单核细胞的浸润在小鼠中明显减弱，其中SIRPα在CD11c ⁺细胞中被特异性消融。该研究为疾病诱导期间引流LNs中自反应性Th17细胞引发的树突状细胞以及疾病高峰期CNS中Th17细胞的浸润或活化提供了新的见解。原始图像被数字化地修改为封面。