Magnetically Responsive Polymeric Microparticles for the Triggered Delivery of a Complex Mixture of Human Placental Proteins,Macromolecular Bioscience

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Magnetically Responsive Polymeric Microparticles for the Triggered Delivery of a Complex Mixture of Human Placental Proteins
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-10-04 , DOI: 10.1002/mabi.202000249
Olivia L Lanier ₁ , Joseph M Ficarrotta ₁ , Isaac Adjei ₁ , Dayita Wable ₁ , Camryn Lewis ₁ , Christopher Nacea ₂ , Blanka Sharma ₁ , Jon Dobson ₁ , Peter McFetridge ₁

Affiliation

Bone loss through traumatic injury is a significant clinical issue. Researchers have created many scaffold types to mimic an extracellular matrix to provide structural support for the formation of new bone, however functional regeneration of larger scaffolds has not been fully achieved. Newer scaffolds aim to deliver bioactive molecules to improve tissue regeneration. To achieve a more comprehensive regenerative response, a magnetically triggerable polymeric microparticle platform is developed for the on‐demand release of a complex mixture of isolated human placental proteins. This system is composed of polycaprolactone (PCL) microparticles, encapsulating magnetic nanoparticles (MNPs), and placental proteins. When subjected to an alternating magnetic field (AMF), the MNPs heat and melt the PCL, enhancing the diffusion of proteins from microparticles. When the field is off, the PCL re‐solidifies. This potentially allows for cyclic drug delivery. Here the design, synthesis, and proof‐of‐concept experiments for this system are reported. In addition, it is shown that the proteins retain function after being magnetically released. The ability to trigger the release of complex protein mixtures on‐demand may provide a significant advantage with wounds where stagnation of healing processes can occur (e.g., large segmented bone defects).

中文翻译：

用于触发递送人胎盘蛋白复杂混合物的磁响应聚合物微粒

外伤引起的骨质流失是一个重要的临床问题。研究人员创造了许多支架类型来模拟细胞外基质，为新骨的形成提供结构支持，但尚未完全实现更大支架的功能再生。较新的支架旨在提供生物活性分子以改善组织再生。为了实现更全面的再生反应，开发了一种可磁性触发的聚合物微粒平台，用于按需释放分离的人类胎盘蛋白的复杂混合物。该系统由聚己内酯 (PCL) 微粒、包裹磁性纳米粒子 (MNP) 和胎盘蛋白组成。当受到交变磁场 (AMF) 的影响时，MNP 会加热并熔化 PCL，增强蛋白质从微粒中的扩散。当场关闭时，PCL 重新凝固。这可能允许循环药物递送。这里报告了该系统的设计、合成和概念验证实验。此外，表明蛋白质在磁性释放后仍保持功能。按需触发复杂蛋白质混合物释放的能力可能为可能发生愈合过程停滞的伤口（例如大的分段骨缺损）提供显着优势。

更新日期：2020-10-04

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