The extracellular matrix (ECM) is a fundamental component of multicellular organisms that orchestrates developmental processes and controls cell and tissue organization. We previously identified the novel ECM protein SNED1 as a promoter of breast cancer metastasis and showed that its level of expression negatively correlated with breast cancer patient survival. Here, we sought to identify the roles of SNED1 during murine development.

中文翻译：

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敲除编码细胞外基质蛋白 SNED1 的基因导致早期新生儿死亡和颅面畸形

细胞外基质 (ECM) 是多细胞生物的基本组成部分，可协调发育过程并控制细胞和组织的组织。我们之前将新型 ECM 蛋白 SNED1 鉴定为乳腺癌转移的启动子，并表明其表达水平与乳腺癌患者的存活率呈负相关。在这里，我们试图确定 SNED1 在小鼠发育过程中的作用。