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Pharmaceuticals and their metabolites in the marine environment: Sources, analytical methods and occurrence
Trends in Environmental Analytical Chemistry ( IF 11.1 ) Pub Date : 2020-10-04 , DOI: 10.1016/j.teac.2020.e00104
Lawrence Mzukisi Madikizela , Somandla Ncube , Hlanganani Tutu , Heidi Richards , Brent Newman , Kuria Ndungu , Luke Chimuka

The occurrence of pharmaceuticals in the environmental waters is a global concern. There is little research conducted on the monitoring of pharmaceuticals in the marine environment. In this article, the occurrence of pharmaceuticals and their metabolites in the coastal waters as well as associated risks related to their uptake by marine organisms are critically reviewed. The literature showed antibiotics as the most plentiful pharmaceuticals in the marine environment. Other therapeutic classes of pharmaceuticals appeared prominently in the marine environment are non-steroidal anti-inflammatory drugs and β-blockers, while gemfibrozil and carbamazepine were singled-out as the most studied lipid regulator and antiepileptic, respectively. Some pharmaceuticals have been found present in the marine organisms that are regarded as important food sources for humans. We reviewed the negative effects associated with the presence of pharmaceuticals in the marine environment. This article is concluded by deliberating on the possible future studies in this research niche area.



中文翻译:

海洋环境中的药物及其代谢物:来源,分析方法和发生情况

药物在环境水域中的出现是全球关注的问题。关于海洋环境中药物监测的研究很少。在本文中,严格审查了沿海水域中药物及其代谢物的发生以及与海洋生物吸收药物有关的相关风险。文献表明,抗生素是海洋环境中最丰富的药物。在海洋环境中显着出现的其他治疗类药物是非甾体类抗炎药和β受体阻滞剂,而吉非贝齐和卡马西平则分别被选为研究最多的脂质调节剂和抗癫痫药。在海洋生物中发现了一些药物,这些药物被认为是人类重要的食物来源。我们审查了与海洋环境中存在的药物有关的负面影响。本文是通过对这一研究领域的可能的未来研究进行总结得出的。

更新日期:2020-10-11
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