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A multivariate analysis of the association between corticostriatal functional connectivity and psychosis-like experiences in the general community
Psychiatry Research: Neuroimaging ( IF 2.1 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.pscychresns.2020.111202
Sara Maria Pani , Kristina Sabaroedin , Jeggan Tiego , Mark A. Bellgrove , Alex Fornito

Dysfunction of dorsal corticostriatal (CST) circuitry is thought to play an important role in psychosis. Here, we use multivariate analysis to characterize covariance between CST functional connectivity and psychosis-like experiences (PLEs) in non-clinical individuals. In 353 healthy adults (155 males), we use partial least squares (PLS) to identify latent variables (LV) describing covariance between seven PLE questionnaire measures and functional connectivity estimated between each of six striatal seed regions and the rest of the brain using multiband resting-state fMRI. Hypothesis-driven PLS of the dorsal caudate (DC) seed identified one significant LV, accounting for 23.88% of covariance, with loadings from nearly all PLE subscales. Cortical regions implicated in this LV comprise anterior cingulate and left dorsolateral prefrontal cortex. Lower connectivity between these cortical areas and the DC seed was associated with more severe PLEs. Using multivariate modeling, we identified an association between dorsal CST connectivity and PLEs in the general community that implicates similar brain regions to those identified in patient groups. Our results highlight that the severity of both positive/negative symptom-like PLEs is related with functional coupling between the DC and dorsolateral PFC, suggesting this neural circuit may play a role in mediating risk for general psychosis-related psychopathology.

中文翻译:

对一般社区皮质纹状体功能连接与精神病样经历之间关联的多变量分析

背侧皮质纹状体 (CST) 回路功能障碍被认为在精神病中起重要作用。在这里,我们使用多变量分析来表征非临床个体的 CST 功能连接和精神病样体验 (PLE) 之间的协方差。在 353 名健康成人(155 名男性)中,我们使用偏最小二乘法 (PLS) 来识别潜在变量 (LV) 来描述七个 PLE 问卷测量之间的协方差以及使用多波段估计的六个纹状体种子区域和大脑其余部分之间的功能连接性静息态 fMRI。背尾尾状核 (DC) 种子的假设驱动 PLS 确定了一个重要的 LV,占协方差的 23.88%,负载来自几乎所有 PLE 子量表。该 LV 中涉及的皮层区域包括前扣带回和左背外侧前额叶皮层。这些皮质区域和 DC 种子之间的较低连接性与更严重的 PLE 相关。使用多变量建模,我们确定了一般社区中背侧 CST 连接和 PLE 之间的关联,这涉及与患者组中确定的大脑区域相似的大脑区域。我们的结果强调,阳性/阴性症状样 PLE 的严重程度与 DC 和背外侧 PFC 之间的功能耦合有关,表明这种神经回路可能在调节一般精神病相关精神病理学的风险中发挥作用。我们在一般社区中确定了背侧 CST 连接和 PLE 之间的关联,这涉及与患者组中确定的大脑区域相似的大脑区域。我们的结果强调,阳性/阴性症状样 PLE 的严重程度与 DC 和背外侧 PFC 之间的功能耦合有关,表明这种神经回路可能在调节一般精神病相关精神病理学的风险中发挥作用。我们在一般社区中确定了背侧 CST 连接和 PLE 之间的关联,这涉及与患者组中确定的大脑区域相似的大脑区域。我们的结果强调,阳性/阴性症状样 PLE 的严重程度与 DC 和背外侧 PFC 之间的功能耦合有关,表明这种神经回路可能在调节一般精神病相关精神病理学的风险中发挥作用。
更新日期:2021-01-01
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