Synthesis and spectroscopic characterization of five ligands ((E)-2-((pyridin-2-ylmethylene)amino)phenol L1, 2-(pyridin-2-yl)benzo[d]thiazole L2, (E)-N-(2-fluorophenyl)-1-(pyridin-2-yl)methanimine L3, (E)-1-(pyridin-2-yl)-N-(p-tolyl)methanimine L4 and (E)-1-(pyridin-2-yl)-N-(thiophen-2-ylmethyl)methanimine L5 along with fifteen silver(I) complexes of L1 – L5, with a general formula [AgL₂]⁺X⁻ (L = Schiff base and X = NO₃⁻, ClO₄⁻ or CF₃SO₃⁻) is reported. The structures of complexes [Ag(L4)₂]NO₃, [Ag(L5)₂]NO₃, [Ag(L3)₂]ClO₄, [Ag(L4)₂]ClO₄ and [Ag(L5)₂]CF₃SO₃ were determined unequivocally by single crystal X-ray diffraction analysis. Calf-thymus deoxyribonucleic acid (CT-DNA), bovine serum albumin (BSA) binding studies, antioxidant, and antibacterial studies were performed for all complexes. Complexes [Ag(L2)₂]NO₃, [Ag(L5)₂]NO₃, [Ag(L1)₂]ClO₄ and [Ag(L3)₂]ClO₄ whose ligands have an OH⁻ and F⁻ as substituents or with a thiophene or thiazole moiety showed better antibacterial activities with lower minimum inhibitory concentration (MIC) values compared to the standard ciprofloxacin, against most of the bacterial strains tested. Similarly, complexes [Ag(L1)₂]NO_3, [Ag(L2)₂]NO_3, [Ag(L3)₂]NO₃ and [Ag(L5)₂]NO₃ with the NO₃⁻ anion, [Ag(L1)₂]ClO₄ and [Ag(L2)₂]ClO₄ with ClO₄⁻ anion, and [Ag(L5)₂]CF₃SO₃ with CF₃SO₃⁻ anion showed higher activities for antioxidant studies. Complexes [Ag(L4)₂]ClO₄ and [Ag(L4)₂]CF₃SO₃ with the Methyl substituent and CF₃SO₃⁻ as the anion, displayed high antioxidant activities in FRAP (ferric reducing antioxidant power) than the standard ascorbic acid. Spectroscopic studies of all the complexes revealed their moderate to high interaction with calf thymus DNA via an intercalation mode. In addition, the relatively moderate interaction of most of the complexes with BSA was through a static quenching mechanism.

五种配体 (( E )-2-((pyridin-2-ylmethylene)amino)phenol L1, 2-(pyridin-2-yl)benzo[ d ]thiazole L2, (E)-N-( 2-氟苯基)-1-(吡啶-2-基)甲胺L3、(E)-1-(吡啶-2-基)-N-(对甲苯基)甲胺L4和(E)-1-(吡啶- 2-yl)-N-(thiophen-2-ylmethyl)methanimine L5以及L1 – L5 的十五个银 (I) 络合物，通式为 [AgL ₂ ] ⁺ X ^- (L = Schiff base and X = NO ₃ ⁻ , ClO ₄ ⁻或 CF ₃ SO ₃⁻ ) 被报告。配合物[ Ag(L4) ₂ ]NO ₃ , [Ag(L5) ₂ ]NO ₃ , [Ag(L3) ₂ ]ClO ₄ , [Ag(L4) ₂ ]ClO ₄和[Ag(L5) _{2 ]的结构}]CF ₃ SO ₃通过单晶X射线衍射分析明确确定。对所有复合物进行了小牛胸腺脱氧核糖核酸 (CT-DNA)、牛血清白蛋白 (BSA) 结合研究、抗氧化剂和抗菌研究。配合物[Ag(L2) ₂ ]NO ₃ , [Ag(L5) ₂]NO ₃、[Ag(L1) ₂ ]ClO ₄和[Ag(L3) ₂ ]ClO ₄其配体具有OH ^-和F ^-作为取代基或具有噻吩或噻唑部分显示出更好的抗菌活性，最低抑菌浓度较低(MIC) 值与标准环丙沙星相比，针对大多数测试的细菌菌株。类似地，络合物[Ag(L1) ₂ ]NO _3、 [Ag(L2) ₂ ]NO _3、 [Ag(L3) ₂ ]NO ₃和[Ag(L5) ₂ ]NO ₃与 NO ₃ ^-阴离子，[Ag(L1) ₂ ]ClO ₄和[Ag(L2) ₂ ]ClO ₄与 ClO ₄ ^-阴离子，和[Ag(L5) ₂ ]CF ₃ SO ₃与 CF ₃ SO ₃ ^-阴离子在抗氧化研究中表现出更高的活性。复合物[Ag(L4) ₂ ]ClO ₄和[Ag(L4) ₂ ]CF ₃ SO ₃与甲基取代基和CF ₃ SO ₃ ^-作为阴离子，在 FRAP（铁还原抗氧化能力）中显示出比标准抗坏血酸高的抗氧化活性。所有复合物的光谱研究揭示了它们通过嵌入模式与小牛胸腺 DNA 中度至高度的相互作用。此外，大多数配合物与 BSA 的相对温和的相互作用是通过静态淬灭机制进行的。