Obesity has been well recognized as an important comorbidity in patients with asthma, representing a unique phenotype and endotype. This association indicates a close relationship between metabolic and inflammatory dysregulation. However, the detailed organ-organ, cellular, and molecular interactions are not completely resolved. Because of that, the relationship between obesity and asthma remains unclear. In this article, clinical and epidemiological studies, as well as data from experimental animal work, are being summarized to provide a state of the art update on this important topic. Much more work is needed, particularly mechanistic, to fully understand the interaction between obesity and asthma and to develop novel preventive and therapeutic strategies.

肥胖已被公认为哮喘患者的重要合并症，代表独特的表型和内型。这种联系表明新陈代谢和炎性调节异常之间的密切关系。但是，详细的器官-器官，细胞和分子相互作用尚未完全解决。因此，肥胖与哮喘之间的关系尚不清楚。在本文中，对临床和流行病学研究以及来自实验动物工作的数据进行了总结，以提供有关此重要主题的最新技术信息。要充分了解肥胖与哮喘之间的相互作用并制定新的预防和治疗策略，还需要做更多的工作，尤其是机械学。