Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-10-04 , DOI: 10.1007/s13659-020-00267-9 Sumel Ashique 1 , Navjot Kaur Sandhu 2 , Sk Niyamul Haque 3 , Kartick Koley 3
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Abstract
Androgens have an intense consequence on the human scalp and body hair. Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens. Androgenetic alopecia (AGA) invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair. Androgens are medium of terminus growth of hair although the body. Local and system androgens convert the extensive terminal follicles into lesser vellus like structure. The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition. Effective treatments are available in the market as well as under clinical and preclinical testing. Many herbal formulations are also available but not FDA approved. Different conventional and NDDS formulations are already available in the market. To avoid various systemic side effects of both Finasteride and Minoxidil, topical formulations and natural products (nutrients, minerals, vitamins) now a days are being widely used to treat Androgenic alopecia. CAM (complementary and alternative medicine) provides the option to elect favorable, low-risk, adjuvant and alternative therapies. Herein, we offer a widespread review of topical marketed formulations, natural products, and CAM treatment options for AGA.
Graphic Abstract
中文翻译：
对预防雄激素性脱发的外用市售制剂、天然产品和口服补充剂的系统评价：综述
抽象的
雄激素对人类头皮和体毛有严重影响。头皮毛发基本上是在雄激素的作用下生长的，而体毛的生长则容易受到雄激素的影响。雄激素性脱发（AGA）被称为男性模仿脱发，由于头皮毛发的动态减少。雄激素是身体毛发末端生长的媒介。局部和系统雄激素将广泛的终末卵泡转化为较小的毳毛状结构。这种类型的脱发的开始是非常不规则的，其背后的原因是存在足够的循环甾体激素雄激素和遗传倾向。市场上已有有效的治疗方法，并且正在进行临床和临床前测试。许多草药配方也可用，但未经 FDA 批准。市场上已有不同的传统配方和 NDDS 配方。为了避免非那雄胺和米诺地尔的各种全身副作用，目前外用制剂和天然产品（营养素、矿物质、维生素）被广泛用于治疗雄激素性脱发。 CAM（补充和替代医学）提供了选择有利的、低风险的辅助和替代疗法的选择。在此，我们对 AGA 的局部市售制剂、天然产品和 CAM 治疗方案进行了广泛的回顾。
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