Exosomes from miRNA‐126‐modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke,CNS Neuroscience & Therapeutics

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Exosomes from miRNA‐126‐modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2020-10-03 , DOI: 10.1111/cns.13455
Jinju Wang ₁ , Shuzhen Chen ₁ , Wenfeng Zhang ₁ , Yanfang Chen ₁ , Ji C Bihl _{1,

2}

Affiliation

We previously showed that the protective effects of endothelial progenitor cells (EPCs)‐released exosomes (EPC‐EXs) on endothelium in diabetes. However, whether EPC‐EXs are protective in diabetic ischemic stroke is unknown. Here, we investigated the effects of EPC‐EXs on diabetic stroke mice and tested whether miR‐126 enriched EPC‐EXs (EPC‐EXs^miR126) have enhanced efficacy.

中文翻译：

来自miRNA-126修饰的内皮祖细胞的外泌体减轻脑损伤并促进中风后的功能恢复

我们之前表明内皮祖细胞（EPCs）释放的外泌体（EPC-EXs）对糖尿病内皮细胞的保护作用。然而，EPC-EXs 是否对糖尿病缺血性卒中具有保护作用尚不清楚。在这里，我们研究了 EPC-EXs 对糖尿病中风小鼠的影响，并测试了富含 miR-126 的 EPC- ^EXs（EPC- ^{EXs miR126}）是否具有增强的功效。

更新日期：2020-12-01

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