Donor Preactivation‐Based Glycosylation: An Efficient Strategy for Glycan Synthesis,Chinese Journal of Chemistry

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Donor Preactivation‐Based Glycosylation: An Efficient Strategy for Glycan Synthesis
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-10-03 , DOI: 10.1002/cjoc.202000484
Xianjin Qin ₁ , Xin‐Shan Ye ₁

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Carbohydrates have gained a lot of appreciation in the past few decades due to their important roles in numerous biological events. Acquiring a structurally well‐defined carbohydrate compound is essential for the understanding of its functions. Although some innovative methods have been developed for the synthesis of complex oligosaccharides, glycan synthesis is in general still a time‐consuming and difficult work. Herein, we will introduce the preactivation‐based glycosylation strategy, which is an efficient protocol independent of the reactivity of glycosyl donor. This review will focus on summarizing the versatile applications of preactivation strategy in stereoselective glycosylation and one‐pot assembly of biologically important oligosaccharides and even polysaccharides.

中文翻译：

供体基于预激活的糖基化：一种有效的聚糖合成策略

由于碳水化合物在众多生物学事件中的重要作用，因此在过去几十年中获得了极大的赞赏。获得结构明确的碳水化合物化合物对于理解其功能至关重要。尽管已开发出一些创新的方法来合成复杂的低聚糖，但聚糖的合成通常仍然是一项耗时且困难的工作。在这里，我们将介绍基于预激活的糖基化策略，这是一种有效的方案，与糖基供体的反应性无关。这篇综述将集中于概述预激活策略在立体选择性糖基化和生物学上重要的低聚糖甚至多糖的一锅组装中的广泛应用。

更新日期：2020-10-03

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